Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/28839
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMillington, William R.-
dc.date.accessioned2022-09-27T06:25:19Z-
dc.date.available2022-09-27T06:25:19Z-
dc.date.issued2010-05-
dc.identifier.citationBaşaran, N. F. vd. (2010). "Glycyl-glutamine (β-endorphin30-31) inhibits morphine-induced dopamine efflux in the nucleus accumbens". Naunyn-Schmiedeberg's Archives of Pharmacology, 381(5), 467-475.en_US
dc.identifier.issn0028-1298-
dc.identifier.issn1432-1912-
dc.identifier.urihttps://doi.org/10.1007/s00210-010-0507-8-
dc.identifier.urihttps://link.springer.com/content/pdf/10.1007/s00210-010-0507-8.pdf-
dc.identifier.urihttp://hdl.handle.net/11452/28839-
dc.description.abstractGlycyl-glutamine (Gly-Gln) is an endogenous dipeptide that is synthesized from beta-endorphin post-translationally. Previously, we showed that Gly-Gln prevents acquisition of morphine-conditioned place preference, a behavioral test of morphine reward, but does not interfere with morphine analgesia. In this study, we tested the hypothesis that Gly-Gln inhibits morphine reward by blocking morphine-induced dopamine efflux in the nucleus accumbens (NAc). Extracellular dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) were sampled by microdialysis and analyzed by high-performance liquid chromatography with electrochemical detection. Guide cannulas were implanted in the right NAc and left lateral ventricle of male Sprague-Dawley rats stereotaxically. Approximately 24 h later, a microdialysis probe was inserted into the NAc and perfused at 1 A mu l/min. Gly-Gln (1, 3, 30, or 100 nmol/5 A mu l) or saline was administered intracerebroventricularly, morphine (2.5 mg/kg) was injected intraperitoneally (i.p.) 2 min later, and extracellular dopamine and DOPAC were sampled at 20-min intervals. Morphine administration increased extracellular dopamine concentrations by approximately 600% within 40 min. Gly-Gln pretreatment inhibited the rise in extracellular dopamine in a dose-related manner; the lowest significantly inhibitory dose was 1 nmol. Gly-Gln also inhibited the morphine-induced rise in extracellular DOPAC concentrations but did not affect extracellular dopamine or DOPAC in control animals. Gly-Gln (100 nmol/5 A mu l) prevented morphine-induced dopamine efflux in rats treated with morphine chronically (10 mg/kg, i.p. twice daily for 6 days), although it did not affect DOPAC concentrations significantly. These data support the hypothesis that Gly-Gln abolishes the rewarding effect of morphine by inhibiting the ability of morphine to stimulate dopamine release in the NAc.en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGlycyl-glutamineen_US
dc.subjectBeta-endorphinen_US
dc.subjectNucleus accumbensen_US
dc.subjectDopamineen_US
dc.subjectMicrodialysisen_US
dc.subjectConditioned place preferenceen_US
dc.subjectNaturally-occurring antagonisten_US
dc.subjectReduces ethanol intakeen_US
dc.subjectRewarden_US
dc.subjectProopiomelanocortinen_US
dc.subjectHypothesisen_US
dc.subjectAddictionen_US
dc.subjectReceptorsen_US
dc.subjectPharmacology & pharmacyen_US
dc.subject.mesh3,4-Dihydroxyphenylaceticaciden_US
dc.subject.meshAnalgesics, opioiden_US
dc.subject.meshAnimalsen_US
dc.subject.meshDipeptidesen_US
dc.subject.meshDopamineen_US
dc.subject.meshDose-response relationship, drugen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrodialysisen_US
dc.subject.meshMorphineen_US
dc.subject.meshNucleus accumbensen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.meshRewarden_US
dc.subject.meshTime factorsen_US
dc.titleGlycyl-glutamine (β-endorphin30-31) inhibits morphine-induced dopamine efflux in the nucleus accumbensen_US
dc.typeArticleen_US
dc.identifier.wos000277258900007tr_TR
dc.identifier.scopus2-s2.0-77953229647tr_TR
dc.relation.tubitakTÜBİTAKtr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı.tr_TR
dc.relation.bapBAPtr_TR
dc.identifier.startpage467tr_TR
dc.identifier.endpage475tr_TR
dc.identifier.volume381tr_TR
dc.identifier.issue5tr_TR
dc.relation.journalNaunyn-Schmiedeberg's Archives of Pharmacologyen_US
dc.contributor.buuauthorFiliz, Nesrin Başaran-
dc.contributor.buuauthorBüyükuysal, Rıfat Levent-
dc.contributor.buuauthorÇavuş, Sinan-
dc.contributor.researcheridAAH-1657-2021tr_TR
dc.contributor.researcheridAAC-9702-2019tr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.identifier.pubmed20349045tr_TR
dc.subject.wosPharmacology & pharmacyen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ2en_US
dc.contributor.scopusid36672447000tr_TR
dc.contributor.scopusid6602686612tr_TR
dc.contributor.scopusid6507468595tr_TR
dc.subject.scopusAging; Amoxicillin; Contractility Invitroen_US
dc.subject.emtree3,4 dihydroxyphenylacetic aciden_US
dc.subject.emtreeDopamineen_US
dc.subject.emtreeGlycylglutamineen_US
dc.subject.emtreeMorphineen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDopamine effluxen_US
dc.subject.emtreeDose responseen_US
dc.subject.emtreeElectrochemical detectionen_US
dc.subject.emtreeExtracellular spaceen_US
dc.subject.emtreeHigh performance liquid chromatographyen_US
dc.subject.emtreeLateral brain ventricleen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMembrane transporten_US
dc.subject.emtreeMicrodialysisen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeNucleus accumbensen_US
dc.subject.emtreeRaten_US
Appears in Collections:Scopus
Web of Science

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.