Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/28984
Title: Effects of oral isotretinoin therapy on peripheral nerve functions: A preliminary study
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabiilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Bölümü.
0000-0002-0193-1128
Aydoğan, Kenan
Karlı, Nejdet
AAH-6216-2021
9739755800
6506587942
Keywords: Dermatology
Neuropathy
Etretinate
Issue Date: Jan-2007
Publisher: Wiley
Citation: Aydoğan, K. ve Karlı, N. (2007). "Effects of oral isotretinoin therapy on peripheral nerve functions: a preliminary study". Clinical and Experimental Dermatology, 32(1), 81-84.
Abstract: Accumulating evidence over the past decade indicates that synthetic retinoids may be capable of affecting both growth and differentiation of nervous tissue. Our aim was to substantiate possible side-effects of oral isotretinoin therapy on peripheral nerve functions, both neurologically and neurophysiologically. We performed neurological examination and electroneuromyographic studies on 18 patients with various skin diseases before, at the third month, and at the end of isotretinoin treatment. Abnormal neurophysiological findings in this study point towards a typical distal, length-dependent and predominantly sensory polyneuropathy. Clinicians should be aware of possible neurological sensorial symptoms during isotretinoin therapy. In our opinion, electroneuromyographic investigation should be performed on all patients reporting symptoms (e.g. paresthesia, numbness, sensory loss) before and during oral isotretinoin treatment. The precise clinical significance of the isotretinoin-induced neurophysiological alterations reported here remains to be determined in further studies.
URI: https://doi.org/10.1111/j.1365-2230.2006.02268.x
https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2230.2006.02268.x
http://hdl.handle.net/11452/28984
ISSN: 1365-2230
0307-6938
Appears in Collections:PubMed
Scopus
Web of Science

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