Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/29041
Title: The IL-33 gene is related to increased susceptibility to systemic sclerosis
Authors: Koca, Süleyman Serdar
Kara, Murat
Alibaz-Öner, Fatma
Öztuzcu, Serdar
Yılmaz, Neslihan
Çetin, Gözde Yıldırım
Kısacık, Bünyamin
Özgen, Metin
Pamuk, Ömer Nuri
Direskeneli, Haner
Sayarlıoğlu, Mehmet
Onat, Ahmet Mesut
Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.
Pehlivan, Yavuz
AAG-8227-2021
13205593600
Keywords: Rheumatology
Systemic sclerosis
Genetic
IL-33 gene polymorphism
Human th2 cells
Disease
Association
ST2
Scleroderma
Fibrosis
Interleukin-4
Polymorphisms
Involvement
Cytokine
Issue Date: 23-Dec-2015
Publisher: Springer Heidelberg
Citation: Koca, S. S. vd. (2015). "The IL-33 gene is related to increased susceptibility to systemic sclerosis". Rheumatology International, 36(4), 579-584.
Abstract: Systemic sclerosis (SSc) is a chronic inflammatory disease characterized by widespread fibrosis of the skin and several visceral organs. The pro-fibrotic potential of interleukin (IL)-33 has been demonstrated by in both in vitro and in vivo settings; moreover, increased level of IL-33 has also been reported in patients with SSc. Therefore, the aim of the present study was to detect the potential association of IL-33 gene polymorphisms on the susceptibility of SSc. A total of 300 SSc patients and 280 healthy controls (HC) were enrolled in this multicentric preliminary candidate gene study. DNA samples were harvested using an appropriate commercial DNA isolation kit. Four single nucleotide polymorphisms (SNPs) of IL-33 gene (rs7044343, rs1157505, rs11792633 and rs1929992) were genotyped using the appropriate commercial primer/probe sets on real-time PCR. There was no significant difference in terms of the allelic distributions and minor allele frequencies of evaluated four IL-33 polymorphisms between the SSc and HC groups (P > 0.05 for all). Moreover, the genotypic distributions of rs1157505, rs11792633 and rs1929992 polymorphisms were not significantly different (P > 0.05 for all). However, CC genotype of rs7044343 SNP was significantly higher in the SSc group compared to the HC group (P = 0.013, OR 1.75, 95 % CI 1.12-2.72). This preliminary candidate gene study demonstrates that rs7044343 polymorphism of IL-33 gene is associated with the susceptibility to the SSc in Turkish population. It may be suggested that IL-33 gene may be a candidate gene to research in SSc.
URI: https://doi.org/10.1007/s00296-015-3417-8
https://link.springer.com/article/10.1007/s00296-015-3417-8
http://hdl.handle.net/11452/29041
ISSN: 0172-8172
1437-160X
Appears in Collections:Scopus
Web of Science

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