Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/29313
Title: Novel 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives: Synthesis, characterization and anticancer activity
Authors: Coşkun, Demet
Ulukaya, Engin
Coşkun, Mehmet Fatih
Uludağ Üniversitesi/Fen Edebiyet Fakültesi/Biyoloji Bölümü.
0000-0002-3127-742X
0000-0002-6729-7908
Erkısa, Merve
Arı, Ferda
AAM-1001-2020
AAG-7012-2021
57126208900
24376085300
Keywords: Chemistry, medicinal
Benzofuran
Chalcone
Cytotoxicity
Anticancer activity
Apoptosis
Biological evaluation
Antioxidant
Activities
Dependent apoptosis
In-vitrocells
Inhibitors
Caspase-3
Pathway
Design
Agents
Issue Date: 18-Aug-2017
Publisher: Elsevier
Citation: Coşkun, D. vd. (2017). ''Novel 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives: Synthesis, characterization and anticancer activity''. European Journal of Medicinal Chemistry, 136, 212-222.
Abstract: Cancer treatment still requires new compounds to be discovered. Chalcone and its derivatives exhibit anticancer potential in different cancer cells. A new series of benzofuran substituted chalcone derivatives was synthesized by the base-catalyzed Claisen-Schmidt reaction of the 1-(7-ethoxy-1-benzofuran-2-yl) ethanone with different aromatic aldehydes to yield 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives 3a-j. The derivatives were characterized by elemental analysis, FT-IR, H-1 NMR and C-13 NMR spectroscopy techniques. The anti-growth effect of chalcone compounds was tested in breast cancer (MCF-7), non-small cell lung cancer (A549) and prostate cancer (PC-3) cell lines by the SRB and ATP cell viability assays. Apoptosis was detected by mitochondrial membrane potential, Annexin V staining and caspase 3/7 activity. Formation of reactive oxygen species was determined by DCFDA. The results revealed that chalcone derivatives have anticancer activity with especially chalcone derivative 3a showing cytotoxic effects on cancer cells. In addition, chalcone derivative 3a induced apoptosis through caspase dependent pathways in prostate, lung and breast cancer cells.
URI: https://doi.org/10.1016/j.ejmech.2017.05.017
https://www.sciencedirect.com/science/article/pii/S0223523417303781
http://hdl.handle.net/11452/29313
ISSN: 0223-5234
1768-3254
Appears in Collections:Scopus
Web of Science

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