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http://hdl.handle.net/11452/29422| Title: | Childhood acute lymphoblastic leukemia with near-tetraplody and t(12; 21) (p13;q22) translocation: A case report |
| Other Titles: | t(12;21)(p13;q22) translokasyonu ve Near Tetraplodi bulunan çocukluk çağı akut lenfoblastik lösemili bir olgu sunumu |
| Authors: | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genel Anabilim Dalı. Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik Hematoloji Anabilim Dalı. Karkucak, Mutlu Yakut, Tahsin Baytan, Birol Gülten, Tuna Güneş, Adalet Meral 35388323500 6602802424 6506622162 6505944216 24072843300 |
| Keywords: | Oncology Childhood acute lymphoblastic leukemia Near-tetraploidy T(12;21) Moleculagenetics Hyperdiploidy Tel-aml1 Children Çocukluk çağı akut lenfoblastik lösemi Near-Tetraplodi, t(12;21) |
| Issue Date: | 2011 |
| Publisher: | Akad Doktorlar Yayınevi |
| Citation: | Karkucak, M. vd. (2011). "Childhood acute lymphoblastic leukemia with near-tetraplody and t(12; 21) (p13;q22) translocation: A case report". UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi, 21(3), 192-195. |
| Abstract: | Fluroscent in situ hybridization analysis indicated presence of t(12;21)(p13;q22) translocation and near-tetraploidy in a case who 11-year-old boy and diagnosed with B precursor acute lymphoblastic leukemia (ALL). Although, some studies suggest good prognostic effect of translocation t(12;21) (p13;q22), there were very little data regarding the prognostic effect of Near-tetraploidy. Here we discussed the prognostic relevance of both t(12;21)(p13;q22) translocation and near tetraplody in Pre-B ALL. Pre- B Akut Lenfoblastik Lösemi tanısı konulan 11 yaşında erkek olguda, Floresans insitu hibridizasyon analizinde t(12;21)(p13;q22) translokasyonu ve near-tetraploidi beraber olduğu gösterilmiştir. Bazı çalışmalarda t(12;21)(p13;q22) trans lokasyonunun iyi prognostik etki oluşturduğu belirtmelerine rağmen near-tetraploidinin prognostik etkisi hakkında çok az bil gi vardır. Burada Pre-B Akut Lenfoblastik Lösemili olguda t(12;21)(p13;q22) translokasyonu ile birlikte near tetraplodi bulgu larının birlikte etkisi tartışılmaktadır. |
| URI: | https://doi.org/10.4999/uhod.09122 http://www.uhod.org/pdf/PDF_479.pdf http://hdl.handle.net/11452/29422 |
| ISSN: | 1306-133X |
| Appears in Collections: | Scopus TrDizin Web of Science |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Karkucak_vd_2011.pdf | 919.41 kB | Adobe PDF |  View/Open |
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