Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/29450
Title: Trans-Dichloridopalladium(II) and platinum(II) complexes with 2-(hydroxymethyl)pyridine and 2-(2-hydroxyethyl)pyridine: Synthesis, structural characterization, DNA binding and in vitro cytotoxicity studies
Authors: Harrison, William T. A.
Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Anabilim Dalı.
Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
0000-0002-6729-7908
0000-0002-2849-3332
0000-0002-2717-2430
İçsel, Ceyda
Yılmaz, Veysel T.
Arı, Ferda
Ulukaya, Engin
AAG-7012-2021
L-7238-2018
K-5792-2018
AAI-3342-2021
55551960400
7006269202
24376085300
6602927353
Keywords: Pharmacology & pharmacy
Transplatinum complexes
2-(Hydroxymethyl)pyridine
2-(2-Hydroxyethyl)pyridine
DNA binding
Cytotoxic activity
Trans geometry
Ethidium-bromide
Metal-complexes
Antitumor
Palladium(II)
Pd(II)
Ligand
Drugs
Ruthenium(II)
Fluorescence
Issue Date: Feb-2013
Publisher: Elsevier France
Citation: İçsel, C. vd. (2013). "Trans-Dichloridopalladium(II) and platinum(II) complexes with 2-(hydroxymethyl)pyridine and 2-(2-hydroxyethyl)pyridine: Synthesis, structural characterization, DNA binding and in vitro cytotoxicity studies". European Journal of Medicinal Chemistry, 60, 386-394 .
Abstract: Four trans-palladium(II)- and trans-platinum(II)-chlorido complexes, trans-[PdCl2(2-hmpy)(2)] (1), trans-[PtCl2(2-hmpy)(2)] (2), trans-[Pdcl(2)(2-hepy)(2)] (3) and trans-[PtCl2(2-hepy)(2)] (4) (2-hmpy = 2-(hydroxymethyl)pyridine and 2-hepy = 2-(2-hydroxyethyl)pyridine), have been synthesized and characterized by elemental analysis, IR, NMR, and X-ray diffraction. The binding properties of these complexes with fish sperm DNA (FS-DNA) were investigated by UV titration, viscosity, thermal denaturation and electrophoresis measurements. The complexes can bind to FS-DNA and complex 4 exhibits the highest binding constant. Gel electrophoresis assay demonstrates that all the complexes can cleave the pCMV-beta gal plasmid DNA to a different degree. The cytotoxic activities of the complexes were tested against four different cancer cell lines. In general, the platinum(II) complexes are more effective than the isostructural palladium(II) complexes. Complex 4 shows high anticancer activity, compared to transplatin, cisplatin, carboplatin and oxaliplatin.
URI: https://doi.org/10.1016/j.ejmech.2012.12.002
https://www.sciencedirect.com/science/article/pii/S0223523412007246
http://hdl.handle.net/11452/29450
ISSN: 0223-5234
1768-3254
Appears in Collections:PubMed
Scopus
Web of Science

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