Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/29506
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dc.date.accessioned2022-11-21T07:28:09Z-
dc.date.available2022-11-21T07:28:09Z-
dc.date.issued2013-02-13-
dc.identifier.citationAybastıer, Ö. vd. (2013). "Response surface optimized ultrasonic-assisted extraction of quercetin and isolation of phenolic compounds from Hypericum perforatum L. by column chromatography". Separation Science and Technology, 48(11), 1665-1674.en_US
dc.identifier.issn0149-6395-
dc.identifier.issn1520-5754-
dc.identifier.urihttps://doi.org/10.1080/01496395.2012.760603-
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/01496395.2012.760603-
dc.identifier.urihttp://hdl.handle.net/11452/29506-
dc.description.abstractThe effects of ultrasonic-assisted extraction factors for the main phenolic compound (quercetin) from Hypericum perforatum L. were optimized using the Box-Behnken design (BBD) combined with response surface methodology. The BBD was employed to evaluate the effects of extraction temperature (30-70 degrees C), extraction time (20-80min), methanol concentration (20-80%, v/v), and HCl concentration (0.8-2.0M) on the content of one of the major phenolic compounds of quercetin. The extracts were analyzed by high performance liquid chromatography (HPLC). The major phenolic compounds of H. perforatum were isolated and the antioxidant capacity and total phenol content were determined in crude extract and fractions. The optimum conditions were determined as extraction temperature 67 degrees C, extraction time 67min, methanol concentration 77% (v/v), and HCl concentration 1.2M. The predicted content of quercetin was 10.81mg/g dried plant under the optimal conditions and the subsequent verification experiment with 11.09mg/g dried plant confirmed the validity of the predicted model. The isolated compounds were identified as quercetin, cyanidin, protocatechuic acid, and kaempferol.en_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChemistryen_US
dc.subjectEngineeringen_US
dc.subjectAntioxidant capacityen_US
dc.subjectHypericum perforatum Len_US
dc.subjectHPLC-DADen_US
dc.subjectIsolationen_US
dc.subjectResponse surface methodologyen_US
dc.subjectUltrasonic-assisted extractionen_US
dc.subjectAntioxidanten_US
dc.subjectFlavonoidsen_US
dc.subjectAciden_US
dc.subjectChromatographyen_US
dc.subjectFlavonoidsen_US
dc.subjectHigh performance liquid chromatographyen_US
dc.subjectMethanolen_US
dc.subjectOptimizationen_US
dc.subjectPhenolsen_US
dc.subjectSurface propertiesen_US
dc.subjectExtractionen_US
dc.titleResponse surface optimized ultrasonic-assisted extraction of quercetin and isolation of phenolic compounds from Hypericum perforatum L. by column chromatographyen_US
dc.typeArticleen_US
dc.identifier.wos000321172700009tr_TR
dc.identifier.scopus2-s2.0-84879909157tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-0380-1992tr_TR
dc.contributor.orcid0000-0003-1508-0181tr_TR
dc.contributor.orcid0000-0002-9381-0410tr_TR
dc.identifier.startpage1665tr_TR
dc.identifier.endpage1674tr_TR
dc.identifier.volume48tr_TR
dc.identifier.issue11tr_TR
dc.relation.journalSeparation Science and Technologyen_US
dc.contributor.buuauthorAybastıer, Önder-
dc.contributor.buuauthorŞahin, Saliha-
dc.contributor.buuauthorDemir, Cevdet-
dc.contributor.researcheridAAH-2892-2021tr_TR
dc.contributor.researcheridX-4621-2018tr_TR
dc.contributor.researcheridABA-2005-2020tr_TR
dc.subject.wosChemistry, multidisciplinaryen_US
dc.subject.wosEngineering, chemicalen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.wos.quartileQ3en_US
dc.contributor.scopusid35344478800tr_TR
dc.contributor.scopusid15027401600tr_TR
dc.contributor.scopusid7003565902tr_TR
dc.subject.scopusAntioxidant; Pseudohypericin; Adhyperforinen_US
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