Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/29568
Title: A reference interval study for common biochemical analytes in Eastern Turkey: A comparison of a reference population with laboratory data mining
Authors: Bakan, Ebubekir
Polat, Harun
Öztürk, Nurinnisa
Baygutalp, Nurcan Kılıç
Umudum, Fatma Zuhal
Bakan, Nuri
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı.
Özarda, Yeşim
AAL-8873-2021
35741320500
Keywords: Medical laboratory technology
Reference intervals
Direct method
Indirect method
Bhattacharya method
Regional differences
Reference values
Worldwide multicenter
Issue Date: 6-Mar-2016
Publisher: Croatian Soc medical Biochemistry & Laboratory Medicine
Citation: Bakan, E. vd. (2016). "A reference interval study for common biochemical analytes in Eastern Turkey: a comparison of a reference population with laboratory data mining". Biochemia Medica, 26(2), 210-223.
Abstract: Introduction: The aim of this study was to define the reference intervals (RIs) in a Turkish population living in Northeast Turkey (Erzurum) for 34 analytes using direct and indirect methods. In the present study, the regional RIs obtained were compared with other RI studies, primarily the nationwide study performed in Turkey. Materials and methods: For the direct method, 435 blood samples were collected from a healthy group of females (N = 218) and males (N = 217) aged between 18 and 65 years. The sera were analysed in Ataturk University hospital laboratory using Roche reagents and analysers for 34 analytes. The data from 1,366,948 records were used to calculate the indirect RIs using a modified Bhattacharya method. Results: Significant gender-related differences were observed for 17 analytes. There were also some apparent differences between RIs derived from indirect and direct methods particularly in some analytes (e.g. gamma-glutamyltransferase, creatine kinase, LDL-cholesterol and iron). The RIs derived with the direct method for some, but not all, of the analytes were generally comparable with the RIs reported in the nationwide study and other previous studies in Turkey. There were large differences between RIs derived by the direct method and the expected values shown in the kit insert (e.g. aspartate aminotransferase, total-cholesterol, HDL-cholesterol, and vitamin B12). Conclusions: These data provide region-specific RIs for 34 analytes determined by the direct and indirect methods. The observed differences in RIs between previous studies could be related to nutritional status and environmental factors.
URI: https://doi.org/10.11613/BM.2016.023
https://www.biochemia-medica.com/en/journal/26/2/10.11613/BM.2016.023
http://hdl.handle.net/11452/29568
ISSN: 1330-0962
1846-7482
Appears in Collections:Scopus
Web of Science

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