Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/29617
Title: Statin therapy may not effect NLR and MPV levels in patients with hypercholesterolemia: A retrospective study
Authors: Beşli, Feyzullah
Başar, Cengiz
Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.
Güngören, Fatih
Çalışkan, Serhat
Polat, Ufuk
Serdar, Osman Akın
AAA-3163-2021
AAF-5116-2019
55747051400
57197111554
56825528100
6507416315
Keywords: Cardiovascular system & cardiology
Statin
Neutrophil-lymphocyte ratio
Mean platelet volume
Coronary artery disease
Cardiovascular risk
Mean platelet volume
C-reactive protein
Coronary-heart-disease
Blood-cell count
Hematologic parameters
Inflammatory markers
Lymphocyte ratio
Artery-disease
Atherosclerosis
Cholesterol
Issue Date: Jul-2016
Publisher: Sage Publications
Citation: Güngören, F. vd. (2016). "Statin therapy may not effect NLR and MPV levels in patients with hypercholesterolemia: A retrospective study". Angiology, 67(6), 536-540.
Abstract: Statins may exert pleiotropic effects in coronary artery disease (CAD), diabetes mellitus, and familial hypercholesterolemia. We evaluated the effects of statins on the neutrophil-lymphocyte ratio (NLR) and mean platelet volume (MPV) in 261 consecutive patients with hypercholesterolemia having CAD or at high cardiovascular (CV) risk and 50 healthy participants who were retrospectively included in this study. Patients were treated with 10 to 80 mg atorvastatin or 10 to 40 mg rosuvastatin for 24 weeks according to baseline levels of cholesterol, triglycerides, and CV risk. Baseline NLR and MPV were significantly higher in patients with CAD or at high risk compared to the control group (1.89 [0.37-6.78]) vs 1.44 [0.75-2.41], P < .001 and 8.8 [6.27-18.6] vs 8.45 [6-11] fL, P = .038, respectively). The NLR, MPV, and lipid parameters were also compared in the patient group after statin treatment for 24 weeks. Lipid levels decreased but the NLR and MPV did not change significantly after the statin therapy. Further studies are needed to clarify the effect of statin therapy on NLR and MPV in patients with CAD or at high CV risk.
URI: https://doi.org/10.1177/0003319715604098
https://journals.sagepub.com/doi/10.1177/0003319715604098
http://hdl.handle.net/11452/29617
ISSN: 0003-3197
1940-1574
Appears in Collections:Scopus
Web of Science

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.