Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/29620
Title: New manganese(II), iron(II), cobalt(II), nickel(II) and copper(II) saccharinate complexes of 2,6-bis(2-benzimidazolyl) pyridine as potential anticancer agents
Authors: Aygün, Muhittin
Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü.
Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.
0000-0001-5238-2432
0000-0002-2717-2430
İçsel, Ceyda
Aydınlık, Şeyma
Yılmaz, Veysel Turan
ABI-2909-2020
AAI-3342-2021
2-s2.0-85087758658
Keywords: Anticancer activity
Apoptosis
First row divalent transition metals
Saccharinate
2,6-Bis(2-benzimidazolyl)pyridine
Ray crystal-structure
Ligand cu(II) complexes
Double-strand breaks
Vivtro DNA-binding
Cell-cycle
Structural-characterization
Antiproliferative activity
Targeting mitochondria
Cytotoxic activity
Cancer-cells
Pharmacology & pharmacy
Issue Date: 2-Jun-2020
Publisher: Elsevier
Citation: İçsel, C. vd. (2020). "New manganese(II), iron(II), cobalt(II), nickel(II) and copper(II) saccharinate complexes of 2,6-bis(2-benzimidazolyl)pyridine as potential anticancer agents". European Journal of Medicinal Chemistry, 202.
Abstract: New mononuclear complexes [Mn(NO3)(sac)(H2O)(bzimpy)]center dot 2DMF (Mn), [Fe(sac)(2)(H2O)(bzimpy)]center dot 2H(2)O (Fe), [Co(bzimpy)(2)](sac)(2)center dot 2H(2)O (Co), [Ni(bzimpy)(2)](sac)(2)center dot H2O center dot i-PrOH (Ni) and [Cu(sac)(2)(bzimpy)]center dot 3DMF (Cu) (sac = saccharinate and bzimpy = 2,6-bis(2-benzimidazolyl)pyridine) were synthesized and structurally characterized by elemental analysis, UV-Vis, IR, ESI-MS and X-ray diffraction. The anticancer activity of the metal complexes against A549 (lung), MCF-7 (breast), HT29 (colon) cancer cells and MCF10A (normal human breast epithelial) cells was tested and compared with those of cisplatin and bzimpy. The complexes displayed potent cytotoxic activity especially in MCF-7 and A549 cell lines, but they were practically inactive against the normal cells. Mechanistic studies with Mn and Cu complexes on A549 cells indicated that the complexes induced G0/G1 arrest. Both complexes increased intracellular ROS (reactive oxygen species) levels and successfully caused both mitochondrial dysfunction and doublestrand DNA breaks. The up-regulated Bax and down-regulated Bcl-2 expression levels, caspase-3/7 activation and reduced Fas expression indicated that Mn and Cu induced ROS-dependent mitochondria-mediated intrinsic apoptosis in A549 cells.
URI: https://doi.org/10.1016/j.ejmech.2020.112535
https://www.sciencedirect.com/science/article/pii/S0223523420305079
http://hdl.handle.net/11452/29620
ISSN: 0223-5234
Appears in Collections:Web of Science

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