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Title: | Combination of fenretinide and indole-3-carbinol results in synergistic cytotoxic activity inducing apoptosis against human breast cancer cells in vitro |
Authors: | Kaçar, Ömer Adıgüzel, Zelal Açılan, Ceyda Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü. Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı. 0000-0002-6729-7908 0000-0003-0463-6818 Cevatemre, Buse Arı, Ferda Sarımahmut, Mehmet Oral, Arzu Yılmaztepe Dere, Egemen Ulukaya, Engin AAG-7012-2021 AHD-2050-2022 AAH-5068-2021 K-5792-2018 A-5841-2017 55693788600 2437608530 44661687400 23091316500 6603627015 6602927353 |
Keywords: | Oncology Pharmacology & pharmacy 3,3 '-diindolylmethane Breast cancer Chemotherapy Cytotoxicity Fenretinide (4-HPR) Indole-3-carbinol Gene-expression Down-regulation Ovarian-cancer Cycle arrest Growth 3,3'-diindolylmethane Death Induction 3,3-diindolylmethane Inhibition |
Issue Date: | Jul-2013 |
Publisher: | Lippincott Williams & Wilkins |
Citation: | Cevatemre, B. vd. (2013). ''Combination of fenretinide and indole-3-carbinol results in synergistic cytotoxic activity inducing apoptosis against human breast cancer cells in vitro". Anti-Cancer Drugs, 24(6), 577-586. |
Abstract: | The outcome in patients with breast cancer is not satisfactory to date, although new chemotherapy regimens have been introduced in clinics. Therefore, novel approaches are required for better management of patients with breast cancer. In this study, we tested the cytotoxic activity of a new combination of fenretinide, a synthetic retinoid, with indole-3-carbinol, a natural product present in vegetables such as broccoli and cabbage, against MCF-7 (estrogen receptor-positive) and MDA-MB-231 (estrogen receptor-negative) cell lines. It has been found that the combination resulted in more powerful cytotoxic activity, by induction of apoptosis, compared with that when they were used singly. In conclusion, this novel combination warrants in-vivo experiments to elucidate its possible use in the treatment of breast cancer. |
URI: | https://doi.org/10.1097/CAD.0b013e328360a921 https://journals.lww.com/anti-cancerdrugs/Fulltext/2013/07000/Combination_of_fenretinide_and_indole_3_carbinol.4.aspx http://hdl.handle.net/11452/29660 |
ISSN: | 0959-4973 1473-5741 |
Appears in Collections: | PubMed Scopus Web of Science |
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