Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/29947
Title: Zn(ii), Cd(ii) and Hg(ii) saccharinate complexes with 2,6-bis(2-benzimidazolyl)pyridine as promising anticancer agents in breast and lung cancer cell linesviaROS-induced apoptosis
Authors: Aygün, Muhittin
Aydınlık, Şeyma
Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü.
0000-0002-2849-3332
0000-0002-2717-2430
İçsel, Ceyda
Yılmaz, Veysel T.
L-7238-2018
AAI-3342-2021
55551960400
56441123900
Keywords: Vitro DNA-binding
Antiproliferative activity
Cytotoxic activity
Crystal-structures
Ligands synthesis
Antibacterial
Palladium(II)
Derivatives
Inhibitors
Chemistry
Biological organs
Cadmium compounds
Cell culture
Cell death
DNA
Electrophoresis
Pyridine
Spectroscopic analysis
Zinc compounds
2 ,6 bis(2 benzimidazolyl)pyridine
Anti-cancer agents
Apoptotic cell death
Cytotoxic activities
Gel electrophoresis
Inhibitory activity
Lung cancer cells
Spectroscopic method
Mercury compounds
Issue Date: 25-May-2020
Publisher: Royal Society Chemistry
Citation: İçsel, C. vd. (2020). "Zn(ii), Cd(ii) and Hg(ii) saccharinate complexes with 2,6-bis(2-benzimidazolyl)pyridine as promising anticancer agents in breast and lung cancer cell linesviaROS-induced apoptosis". Dalton Transactions, 49(29), 7842-7851.
Abstract: New Zn(ii), Cd(ii) and Hg(ii) complexes of saccharinate (sac) and 2,6-bis(2-benzimidazolyl)pyridine (bzimpy), [Zn(bzimpy)(2)](sac)(2)center dot 2H(2)O (Zn), [Cd(sac)(2)(bzimpy)] (Cd) and [Hg(sac)(2)(bzimpy)] (Hg), were prepared and fully characterized by spectroscopic methods and X-ray crystallography.In vitroanticancer screening in A549 (lung), MCF-7 (breast) and HT29 (colon) cell lines showed thatZnwas highly cytotoxic against A549 and MCF-7 cells with IC(50)values of 1.74 +/- 0.06 and 3.15 +/- 0.10 mu M, respectively, andHgdemonstrated potent cytotoxic activity in MCF-7 cells (8.61 +/- 0.98 mu M), whileCdand bzimpy exhibited moderate growth inhibitory activities in all of the cell lines. In addition, they showed significantly lower toxicity towards normal human breast epithelial MCF10A cells. Moreover, the complexes exhibited significantly high nuclease activity towards plasmid DNA and their interactions with DNA were assessed by gel electrophoresis and DNA docking.ZnandHginduced G0/G1 cell arrest and apoptotic cell death detectedviatypical DNA condensation/fragmentation, annexin V staining and caspase 3/7 activity in A549 and MCF-7 cells. These complexes further caused depolarization of mitochondria and oxidative damage of genomic DNA following excessive production of reactive oxygen species (ROS).
URI: https://doi.org/10.1039/d0dt01535k
https://pubs.rsc.org/en/content/articlelanding/2020/DT/D0DT01535K
http://hdl.handle.net/11452/29947
ISSN: 1477-9226
1477-9234
Appears in Collections:PubMed
Scopus
Web of Science

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