Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/29990
Title: Glutathione S-transferase M1 and T1 gene polymorphisms in patients with chronic plaque-type psoriasis: A case-control study
Authors: Solak, Berna
Karkucak, Mutlu
Turan, Hakan
Uslu, Esma
Erdem, Teoman
Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.
Ocakoğlu, Gökhan
Sağ, Şebnem Özemri
Yakut, Tahsin
AAH-8355-2021
AAH-5180-2021
57073882900
57116515700
6602802424
Keywords: General & internal medicine
Gene polymorphisms
Glutathione S-transferase
Psoriasis
Cancer risk
Susceptibility
Association
Population
Genotype
Sensitivity
Skin
Issue Date: 3-Nov-2015
Publisher: Karger
Citation: Solak, B. vd. (2016). "Glutathione S-transferase M1 and T1 gene polymorphisms in patients with chronic plaque-type psoriasis: A case-control study". Medical Principles and Practice, 25(2), 155-158.
Abstract: Objective: To determine the role of glutathione S-transferase (GST) isoenzyme polymorphisms as susceptibility factors in patients with psoriasis in a Turkish cohort. Subjects and Methods: In this case-control study, 105 patients with plaque-type psoriasis and 102 healthy controls were recruited from the dermatology outpatient clinics of two university hospitals. Genomic DNA was extracted from whole blood using a DZ DNA isolation kit. Multiplex PCR was used to determine GSTM1 and GSTT1 polymorphisms in the isolated DNAs. Results: Of the 150 patients with psoriasis, 83 (79%) were identified with the GSTT1 genotype and 22 (21%) with the null genotype. Of the 102 patients in the control group, 69 (67.6%) subjects were identified with the GSTT1 genotype and 33 (32.4%) with the null genotype. There was no significant difference between the patient and control groups (p = 0.063). Regarding the GSTM1 polymorphism, 54 (51.4%) patients were identified with this genotype and 51 (48.6%) with the null genotype; in the control group, 50 (49%) were identified with this genotype and 52 (51%) with the null genotype. Again there was no statistically significant difference between the groups (p = 0.957). Conclusion: In this Turkish cohort of patients with psoriasis, neither GSTT1 nor GSTM1 polymorphisms were associated with disease susceptibility. Larger studies with a wider range of GST isoenzyme are needed.
URI: https://doi.org/10.1159/000442165
https://www.karger.com/Article/FullText/442165
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588339/
http://hdl.handle.net/11452/29990
ISSN: 1011-7571
1423-0151
Appears in Collections:Scopus
Web of Science

Files in This Item:
File Description SizeFormat 
Ocakoğlu_vd_2016.pdf365.99 kBAdobe PDFThumbnail
View/Open


This item is licensed under a Creative Commons License Creative Commons