Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/30078
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dc.contributor.authorBouhri, Youcef-
dc.contributor.authorAşkun, Tülin-
dc.contributor.authorDeniz, Görkem-
dc.date.accessioned2022-12-26T07:32:46Z-
dc.date.available2022-12-26T07:32:46Z-
dc.date.issued2019-11-25-
dc.identifier.citationBouhri, Y. vd. (2020). "The orange-red pigment from Penicillium mallochii: Pigment production, optimization, and pigment efficacy against Glioblastoma cell lines". Biocatalysis and Agricultural Biotechnology, 23.en_US
dc.identifier.issn1878-8181-
dc.identifier.urihttps://doi.org/10.1016/j.bcab.2019.101451-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1878818119310722-
dc.identifier.urihttp://hdl.handle.net/11452/30078-
dc.description.abstractThe red-orange pigment producer strain Penicillium mallochii (TACB-16) used in this study was isolated from beech tree bark in Balikesir, Turkey, and was identified by molecular methods (P. mallochii Genbank accession number: MG591446). P. mallochii Rivera, Urb & Seifert was first isolated from the caterpillars Rothschildia lebeau and Citheronia lobesis on Costa Rica and is a new record for Turkey. Little is known of this fungus. In this study, the pigment production of P. mallochii on different media was characterised, and the factors affecting the pigment production and efficacy against the human GB cell line T98G cell viability/cytotoxicity were inspected. The results showed that the pigment was resistant to different temperatures and pH values. The -250 base pair of the ITS region was sequenced and submitted to the Genbank. The blast result of the sequence showed that our isolate displayed maximum similarity (100%) to P. mallochii. Glioblastoma (grade-IV astrocytoma, WHO) is the most lethal subtype of glioma and the survival rate of GB patients is still low. Our results suggest that the pigment exhibits anti-proliferative effects on the T98G cell line. The present study is the first to assess the cytotoxic effect of the pigment on the survival of GB cells. Further studies and validations are needed, but we suggest that the pigment might be used for in vitro and in vivo studies, food industry and for future medical drug studies.en_US
dc.description.sponsorshipResearch Foundation of Balikesir University (2017/075)en_US
dc.description.sponsorshipFirat University Scientific Research Projects Management Uniten_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPenicillium mallochiien_US
dc.subjectNatural colourantsen_US
dc.subjectPigmenten_US
dc.subjectSecondary metabolitesen_US
dc.subjectAnti-canceren_US
dc.subjectGlioblastoma cellsen_US
dc.subjectFilamentous fungien_US
dc.subjectNatural pigmentsen_US
dc.subjectMonascus SPen_US
dc.subjectCarotenoidsen_US
dc.subjectAntioxidanten_US
dc.subjectTemperatureen_US
dc.subjectMetabolitesen_US
dc.subjectPolyketideen_US
dc.subjectColorantsen_US
dc.subjectGrowthen_US
dc.subjectBiotechnology & applied microbiologyen_US
dc.titleThe orange-red pigment from Penicillium mallochii: Pigment production, optimization, and pigment efficacy against Glioblastoma cell linesen_US
dc.typeArticleen_US
dc.identifier.wos000529379500017tr_TR
dc.identifier.scopus2-s2.0-85075839729tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-1619-6680tr_TR
dc.contributor.orcid0000-0002-3760-9755tr_TR
dc.identifier.volume23tr_TR
dc.relation.journalBiocatalysis and Agricultural Biotechnologyen_US
dc.contributor.buuauthorTunca, Berrin-
dc.contributor.buuauthorAksoy, Seçil-
dc.contributor.buuauthorMutlu, Melis-
dc.contributor.researcheridFPB-0403-2022tr_TR
dc.relation.collaborationYurt içitr_TR
dc.subject.wosBiotechnology & applied microbiologyen_US
dc.indexed.wosESCIen_US
dc.indexed.scopusScopusen_US
dc.contributor.scopusid6602965754tr_TR
dc.contributor.scopusid57193933334tr_TR
dc.contributor.scopusid57212065763tr_TR
dc.subject.scopusPigments; Red Yeast Rice; Citrininen_US
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