1. Açık Erişim@BUU
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Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/30129
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dc.contributor.authorFranco-Martínez, Lorena-
dc.contributor.authorTvarijonaviciute, Asta-
dc.contributor.authorHorvatić, Anita-
dc.contributor.authorGuillemin, Nicolas-
dc.contributor.authorCerón, José Joaquín-
dc.contributor.authorEscribano, Damián-
dc.contributor.authorEckersall, David-
dc.contributor.authorLamy, Elsa-
dc.contributor.authorMartínez-Subiela, Silvia-
dc.contributor.authorMrljak, Vladimir-
dc.date.accessioned2022-12-28T08:50:33Z-
dc.date.available2022-12-28T08:50:33Z-
dc.date.issued2018-09-18-
dc.identifier.citationFranco-Martínez, L. vd. (2018). ''Changes in salivary analytes in canine parvovirus: A high-resolution quantitative proteomic study''. Comparative Immunology, Microbiology and Infectious Diseases, 60, 1-10.en_US
dc.identifier.issn0147-9571-
dc.identifier.issn1878-1667-
dc.identifier.urihttps://doi.org/10.1016/j.cimid.2018.09.011-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0147957118300742-
dc.identifier.urihttp://hdl.handle.net/11452/30129-
dc.description.abstractThe present study evaluated the changes in salivary proteome in parvoviral enteritis (PVE) in dogs through a high-throughput quantitative proteomic analysis. Saliva samples from healthy dogs and dogs with severe parvovirosis that survived or perished due to the disease were analysed and compared by Tandem Mass Tags (TMT) analysis. Proteomic analysis quantified 1516 peptides, and 287 (corresponding to 190 proteins) showed significantly different abundances between studied groups. Ten proteins were observed to change significantly between dogs that survived or perished due to PVE. Bioinformatics' analysis revealed that saliva reflects the involvement of different pathways in PVE such as catalytic activity and binding, and indicates antimicrobial humoral response as a pathway with a major role in the development of the disease. These results indicate that saliva proteins reflect physiopathological changes that occur in PVE and could be a potential source of biomarkers for this disease.en_US
dc.description.sponsorshipFPU of University of Murcia, Spainen_US
dc.description.sponsorshipMinisterio de Economia y Competitividad, Spainen_US
dc.description.sponsorshipProgram for Research Groups of Excellence of the Seneca Foundation, Murcia, Spain (19894/GERM/15)en_US
dc.description.sponsorshipEuropean Commission ERA chair FP7 grant (621394)en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectImmunologyen_US
dc.subjectMicrobiologyen_US
dc.subjectVeterinary sciencesen_US
dc.subjectBioinformaticsen_US
dc.subjectBiomarkeren_US
dc.subjectCanine parvovirosisen_US
dc.subjectDogen_US
dc.subjectLabel-based proteomicsen_US
dc.subjectSalivaen_US
dc.subjectHistidine-rich glycoproteinen_US
dc.subjectAcute-phase proteinsen_US
dc.subjectDogsen_US
dc.subjectBiomarkersen_US
dc.subjectInfectionen_US
dc.subjectIdentificationen_US
dc.subjectDiagnosisen_US
dc.subjectEnteritisen_US
dc.subjectLipocalinen_US
dc.subjectSerumen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiomarkersen_US
dc.subject.meshComputational biologyen_US
dc.subject.meshDog diseasesen_US
dc.subject.meshDogsen_US
dc.subject.meshEnteritisen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshParvoviridae infectionsen_US
dc.subject.meshParvovirus, canineen_US
dc.subject.meshProteomicsen_US
dc.subject.meshSalivaen_US
dc.subject.meshSalivary proteins and peptidesen_US
dc.titleChanges in salivary analytes in canine parvovirus: A high-resolution quantitative proteomic studyen_US
dc.typeArticleen_US
dc.identifier.wos000449071800001tr_TR
dc.identifier.scopus2-s2.0-85054338485tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Veterinerlik Fakültesi/Dahiliye Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-9836-0749tr_TR
dc.identifier.startpage1tr_TR
dc.identifier.endpage10tr_TR
dc.identifier.volume60tr_TR
dc.relation.journalComparative Immunology, Microbiology and Infectious Diseasesen_US
dc.contributor.buuauthorKocatürk, Meriç-
dc.contributor.buuauthorYılmaz, Zeki-
dc.contributor.researcheridV-5578-2017tr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.identifier.pubmed30396423tr_TR
dc.subject.wosImmunologyen_US
dc.subject.wosMicrobiologyen_US
dc.subject.wosVeterinary sciencesen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ1 (Veterinary sciences)en_US
dc.wos.quartileQ4en_US
dc.contributor.scopusid36437200800tr_TR
dc.contributor.scopusid35944810500tr_TR
dc.subject.scopusCanine Parvovirus; Feline Panleukopenia Virus; Dogen_US
dc.subject.emtreeAlpha actinin 1en_US
dc.subject.emtreeAmikacinen_US
dc.subject.emtreeAmpicillinen_US
dc.subject.emtreeApolipoprotein A1en_US
dc.subject.emtreeBiological markeren_US
dc.subject.emtreeBPI fold containing family B member 2 proteinen_US
dc.subject.emtreeCathelicidin antimicrobial peptideen_US
dc.subject.emtreeCD177 antigenen_US
dc.subject.emtreeClusterinen_US
dc.subject.emtreeCystatin Men_US
dc.subject.emtreeEF hand domain containing protein D2en_US
dc.subject.emtreeEzrinen_US
dc.subject.emtreeGelatinase Ben_US
dc.subject.emtreeGlutathione derivativeen_US
dc.subject.emtreeHemoglobin beta chainen_US
dc.subject.emtreeImmunoglobulin heavy chainen_US
dc.subject.emtreeLactoperoxidaseen_US
dc.subject.emtreeLactoylglutathione lyaseen_US
dc.subject.emtreeLeukocyte elastaseen_US
dc.subject.emtreeLipocalin 9en_US
dc.subject.emtreeMetronidazoleen_US
dc.subject.emtreePlastin 2en_US
dc.subject.emtreeProteomeen_US
dc.subject.emtreeRetinol binding protein 4en_US
dc.subject.emtreeRho GDP dissociation inhibitor beta proteinen_US
dc.subject.emtreeSaliva proteinen_US
dc.subject.emtreeTrefoil factor 1en_US
dc.subject.emtreeUbiquitin Cen_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeUnindexed drugen_US
dc.subject.emtreeVitamin D binding proteinen_US
dc.subject.emtreeBiological markeren_US
dc.subject.emtreeSaliva proteinen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBioinformaticsen_US
dc.subject.emtreeCanine parvovirusen_US
dc.subject.emtreeCatalysisen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDisease severityen_US
dc.subject.emtreeDogen_US
dc.subject.emtreeDown regulationen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHigh resolution quantitative proteomic analysisen_US
dc.subject.emtreeHigh throughput screeningen_US
dc.subject.emtreeHumoral immunityen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeParvovirosisen_US
dc.subject.emtreeParvovirus infectionen_US
dc.subject.emtreePathophysiologyen_US
dc.subject.emtreeProtein analysisen_US
dc.subject.emtreeProtein bindingen_US
dc.subject.emtreeProtein expressionen_US
dc.subject.emtreeProtein functionen_US
dc.subject.emtreeProteomicsen_US
dc.subject.emtreeQuantitative analysisen_US
dc.subject.emtreeSalivaen_US
dc.subject.emtreeSaliva analysisen_US
dc.subject.emtreeSurvivalen_US
dc.subject.emtreeTandem mass spectrometryen_US
dc.subject.emtreeTandem Mass Tags based proteomic analysisen_US
dc.subject.emtreeUpregulationen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeBiologyen_US
dc.subject.emtreeCanine parvovirusen_US
dc.subject.emtreeChemistryen_US
dc.subject.emtreeDog diseaseen_US
dc.subject.emtreeEnteritisen_US
dc.subject.emtreeImmunologyen_US
dc.subject.emtreeIsolation and purificationen_US
dc.subject.emtreeMortalityen_US
dc.subject.emtreeParvovirus infectionen_US
dc.subject.emtreeProteomicsen_US
dc.subject.emtreeSalivaen_US
dc.subject.emtreeVeterinary medicineen_US
dc.subject.emtreeVirologyen_US
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