Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/30265
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dc.date.accessioned2023-01-05T06:14:38Z-
dc.date.available2023-01-05T06:14:38Z-
dc.date.issued2016-05-03-
dc.identifier.citationTufan, A. N. vd. (2017). ''Prolonged Tpeak-Tend interval in anti-Ro52 antibody-positive connective tissue diseases''. Rheumatology International, 37(1), 67-73.en_US
dc.identifier.issn0172-8172-
dc.identifier.urihttps://doi.org/10.1007/s00296-016-3488-1-
dc.identifier.urihttps://link.springer.com/article/10.1007/s00296-016-3488-1-
dc.identifier.uri1437-160X-
dc.identifier.urihttp://hdl.handle.net/11452/30265-
dc.description.abstractPatients with connective tissue diseases (CTDs) may have prolonged corrected QT interval which indicates increased risk for ventricular arrhythmias. However, a more sensitive measure of ventricular repolarization, T-peak-to-end (Tpe) interval, has not been studied in CTDs. We aimed to investigate the relationship between ventricular repolarization abnormalities and anti-Ro52-positivity in subjects with connective tissue diseases (CTDs). We enrolled patients with anti-Ro52-positive CTDs, ANA-positive CTDs, and healthy subjects in this cross-sectional study. We excluded conditions potentially affecting the QT interval. We compared the ECG measures between the groups and performed analyses to define factors associated with ventricular repolarization measures. 15 ANA and anti-Ro52-positive, 39 ANA-positive and anti-Ro52-negative, and 22 healthy subjects were enrolled. None of the subjects had rhythm or conduction disturbances. Corrected QT intervals were similar between the groups. Tpe (84, 77.3, and 69.4 msn, respectively) and QT-dispersion (40, 27.2, and 20.1 msn, respectively) were higher in anti-Ro52-positive subjects compared with the ANA-positive and healthy subjects. Anti-Ro52 titers were correlated with Tpe and QT-dispersion (r = 0.52 and p < 0.001 for each). ANA and anti-Ro52-positivity were independently associated with higher Tpe (OR = 7.7, p = 0.001 and OR = 6.9, p = 0.001, respectively), corrected Tpe (OR = 11.3, p = 0.001 and OR = 8.4, p = 0.003, respectively), QT dispersion (OR = 7, p = 0.008 and OR = 13, p < 0.001, respectively), and QTc dispersion (OR = 9.1, p = 0.001 and OR = 14.1, p < 0.001, respectively). This study provides evidence that ANA positivity, especially when concomitant anti-Ro52-positivity is present, significantly deteriorates ventricular repolarization. The aforementioned ventricular repolarization abnormalities may render these subjects susceptible to serious rhythm or conduction disorders in the setting of predisposing conditions.en_US
dc.description.sponsorshipBursa Böbrek Vakfıtr_TR
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRheumatologyen_US
dc.subjectAnti-Ro52en_US
dc.subjectArrhythmiaen_US
dc.subjectConnective tissue diseaseen_US
dc.subjectTpeak-tenden_US
dc.subjectVentricular repolarizationen_US
dc.subjectSystemic-lupus-erythematosusen_US
dc.subjectCorrected qt intervalen_US
dc.subjectCongenital heart-blocken_US
dc.subjectCardiac autonomic dysfunctionen_US
dc.subjectTp-e/qt ratioen_US
dc.subjectRheumatoid-arthritisen_US
dc.subjectRo/ssa antibodiesen_US
dc.subjectAtrioventricular-blocken_US
dc.subjectSsa/ro antibodiesen_US
dc.subjectRo antibodiesen_US
dc.subject.meshAdulten_US
dc.subject.meshArrhythmias, cardiacen_US
dc.subject.meshAutoantibodiesen_US
dc.subject.meshConnective tissue diseasesen_US
dc.subject.meshCross-sectional studiesen_US
dc.subject.meshElectrocardiographyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart conduction systemen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshRibonucleoproteinsen_US
dc.titleProlonged Tpeak-Tend interval in anti-Ro52 antibody-positive connective tissue diseasesen_US
dc.typeArticleen_US
dc.identifier.wos000392329100009tr_TR
dc.identifier.scopus2-s2.0-84976621858tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0298-4157tr_TR
dc.contributor.orcid0000-0001-8404-8252tr_TR
dc.identifier.startpage67tr_TR
dc.identifier.endpage73tr_TR
dc.identifier.volume37tr_TR
dc.identifier.issue1tr_TR
dc.relation.journalRheumatology Internationalen_US
dc.contributor.buuauthorTufan, Ayşe Nur-
dc.contributor.buuauthorSağ, Saim-
dc.contributor.buuauthorÖksüz, Ferhat-
dc.contributor.buuauthorErmurat, Selime-
dc.contributor.buuauthorCoşkun, Belkıs Nihan-
dc.contributor.buuauthorGüllülü, Mustafa-
dc.contributor.buuauthorBudak, Ferah-
dc.contributor.buuauthorBaran, İbrahim-
dc.contributor.buuauthorPehlivan, Yavuz-
dc.contributor.buuauthorDalkılıç, Ediz-
dc.contributor.researcheridAAG-7155-2021tr_TR
dc.contributor.researcheridAAW-9185-2020tr_TR
dc.contributor.researcheridF-4657-2014tr_TR
dc.contributor.researcheridAAG-8227-2021tr_TR
dc.identifier.pubmed27193468tr_TR
dc.subject.wosRheumatologyen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.contributor.scopusid56076552900tr_TR
dc.contributor.scopusid12140008100tr_TR
dc.contributor.scopusid56016440100tr_TR
dc.contributor.scopusid55371331300tr_TR
dc.contributor.scopusid55646165400tr_TR
dc.contributor.scopusid6602684544tr_TR
dc.contributor.scopusid6701913697tr_TR
dc.contributor.scopusid35572557400tr_TR
dc.contributor.scopusid57220381538tr_TR
dc.contributor.scopusid6506739457tr_TR
dc.subject.scopusNeonatal Systemic Lupus Erythematosus; Congenital Heart Block; Pregnancyen_US
dc.subject.emtreeAntinuclear antibodyen_US
dc.subject.emtreeRo antibodyen_US
dc.subject.emtreeAutoantibodyen_US
dc.subject.emtreeRibonucleoproteinen_US
dc.subject.emtreeSS-A antigenen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAntibody titeren_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeClinical assessmenten_US
dc.subject.emtreeConnective tissue diseaseen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCross-sectional studyen_US
dc.subject.emtreeElectrocardiogramen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHeart muscle conduction disturbanceen_US
dc.subject.emtreeHeart repolarizationen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeQT dispersionen_US
dc.subject.emtreeQTc intervalen_US
dc.subject.emtreeSerologyen_US
dc.subject.emtreeT peak to end intervalen_US
dc.subject.emtreeConnective tissue diseaseen_US
dc.subject.emtreeElectrocardiographyen_US
dc.subject.emtreeHeart arrhythmiaen_US
dc.subject.emtreeHeart muscle conduction systemen_US
dc.subject.emtreeImmunologyen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreePathophysiologyen_US
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