Please use this identifier to cite or link to this item:
http://hdl.handle.net/11452/30337
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.date.accessioned | 2023-01-09T10:56:13Z | - |
dc.date.available | 2023-01-09T10:56:13Z | - |
dc.date.issued | 2017-04-20 | - |
dc.identifier.citation | Güney, İ. V. vd. (2017). ''The effect of early administration of combined multi-strain and multi-species probiotics on gastrointestinal morbidities and mortality in preterm infants: A randomized controlled trial in a tertiary care unit''. Turkish Journal of Pediatrics, 59(1), 13-19. | tr_TR |
dc.identifier.issn | 0041-4301 | - |
dc.identifier.uri | https://doi.org/10.24953/turkjped.2017.01.003 | - |
dc.identifier.uri | http://www.turkishjournalpediatrics.org/abstract.php?id=1672 | - |
dc.identifier.uri | http://hdl.handle.net/11452/30337 | - |
dc.description.abstract | Necrotizing enterocolitis (NEC) is a gastrointestinal emergency of the neonatal period. The aim of this study was to demonstrate the use of multistrain and multispecies probiotic on gastrointestinal morbidities and mortality. The study was organized as a randomized controlled, prospective study in premature infants (<= 32 week and <= 1500 gram). The ready commercial preparations which contain multi-combined probiotics of Lactobacillus rhamnosus (4.1x10(8) cfu) + Lactobacillus casei (8.2x10(8) cfu) + Lactobacillus plantorum (4.1x10(8) cfu) + Bifidobacterium animalis (4.1x10(8) cfu) together with 383 mg of fructooligosaccharides and 100 mg of galactooligosaccharides as the prebiotic content, was administered enterally to the probiotic group (n=70); control group constituted of 40 preterms. Primary outcomes of the present study were >= Stage 2 NEC and the mortality. Secondary outcomes were culture-proven sepsis and days to reach full enteral feeding. All cases of NEC were seen in group 2 as 3.6% (n=4) of all infants. The mortality was found to be 1.4% (n=1) in Group 1 and 22.5% (n=9) in Group 2. The incidence of NEC and the mortality rate were found to be significantly lower in Group 1 (p=0.016, p=0.001, respectively). In Group 1, the NEC-related mortality rate and sepsis-related mortality rate were significantly lower than that of the control group (p=0.046, p=0.023). In this study, we showed that using probiotic strains in combined multistrain and multispecies forms at higher doses and for prolonged duration had positive effects on gastrointestinal complications, sepsis and mortality in premature infants. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Türk Pediatri Dergisi | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Atıf Gayri Ticari Türetilemez 4.0 Uluslararası | tr_TR |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Pediatrics | en_US |
dc.subject | Feeding intolerance | en_US |
dc.subject | Necrotizing enterocolitis | en_US |
dc.subject | Newborn | en_US |
dc.subject | Probiotics | en_US |
dc.subject | Sepsis | en_US |
dc.subject | Birth-weight infants | en_US |
dc.subject | Prevent necrotizing enterocolitis | en_US |
dc.subject | Prophylactic probiotics | en_US |
dc.subject | Updated metaanalysis | en_US |
dc.subject | Oral supplementation | en_US |
dc.subject | Double-blind | en_US |
dc.subject | Sepsis | en_US |
dc.subject | Infection | en_US |
dc.subject | Risk | en_US |
dc.subject.mesh | Enteral nutrition | en_US |
dc.subject.mesh | Enterocolitis, necrotizing | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Incidence | en_US |
dc.subject.mesh | Infant | en_US |
dc.subject.mesh | Infant mortality | en_US |
dc.subject.mesh | Infant, newborn | en_US |
dc.subject.mesh | Infant, premature | en_US |
dc.subject.mesh | Infant, premature, diseases | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Probiotics | en_US |
dc.subject.mesh | Prospective studies | en_US |
dc.subject.mesh | Sepsis | en_US |
dc.subject.mesh | Tertiary healthcare | en_US |
dc.subject.mesh | Time factors | en_US |
dc.subject.mesh | Treatment outcome | en_US |
dc.title | The effect of early administration of combined multi-strain and multi-species probiotics on gastrointestinal morbidities and mortality in preterm infants: A randomized controlled trial in a tertiary care unit | en_US |
dc.type | Article | en_US |
dc.identifier.wos | 000416303200003 | tr_TR |
dc.identifier.scopus | 2-s2.0-85035040563 | tr_TR |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı. | tr_TR |
dc.identifier.startpage | 13 | tr_TR |
dc.identifier.endpage | 19 | tr_TR |
dc.identifier.volume | 59 | tr_TR |
dc.identifier.issue | 1 | tr_TR |
dc.relation.journal | Turkish Journal of Pediatrics | en_US |
dc.contributor.buuauthor | Güney, İpek Varal | - |
dc.contributor.buuauthor | Köksal, Nilgün | - |
dc.contributor.buuauthor | Özkan, Hilal | - |
dc.contributor.buuauthor | Bağcı, Onur | - |
dc.contributor.buuauthor | Doğan, Pelin | - |
dc.contributor.researcherid | AAG-8393-2021 | tr_TR |
dc.contributor.researcherid | AAI-5981-2020 | tr_TR |
dc.identifier.pubmed | 29168358 | tr_TR |
dc.subject.wos | Pediatrics | en_US |
dc.indexed.wos | SCIE | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.pubmed | PubMed | en_US |
dc.wos.quartile | Q4 | en_US |
dc.contributor.scopusid | 57197818259 | tr_TR |
dc.contributor.scopusid | 7003323615 | tr_TR |
dc.contributor.scopusid | 16679325400 | tr_TR |
dc.contributor.scopusid | 20733563300 | tr_TR |
dc.contributor.scopusid | 55316686500 | tr_TR |
dc.subject.scopus | Necrotizing Enterocolitis; Prematurity; Newborn | en_US |
dc.subject.emtree | Ructose oligosaccharide | en_US |
dc.subject.emtree | Galactose oligosaccharide | en_US |
dc.subject.emtree | NBL probiotic | en_US |
dc.subject.emtree | Placebo | en_US |
dc.subject.emtree | Probiotic agent | en_US |
dc.subject.emtree | Probiotic agent | en_US |
dc.subject.emtree | Antibiotic therapy | en_US |
dc.subject.emtree | Apgar score | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Bifidobacterium animalis | en_US |
dc.subject.emtree | Birth weight | en_US |
dc.subject.emtree | Chromosome aberration | en_US |
dc.subject.emtree | Clinical feature | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Enteric feeding | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Follow up | en_US |
dc.subject.emtree | Gestational age | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Lactobacillus casei | en_US |
dc.subject.emtree | Lactobacillus rhamnosus | en_US |
dc.subject.emtree | Length of stay | en_US |
dc.subject.emtree | Major clinical study | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Metabolic disorder | en_US |
dc.subject.emtree | Mortality rate | en_US |
dc.subject.emtree | Multiple pregnancy | en_US |
dc.subject.emtree | Necrotizing enterocolitis | en_US |
dc.subject.emtree | Neonatal intensive care unit | en_US |
dc.subject.emtree | Newborn | en_US |
dc.subject.emtree | Newborn period | en_US |
dc.subject.emtree | Outcome assessment | en_US |
dc.subject.emtree | Power analysis | en_US |
dc.subject.emtree | Preeclampsia | en_US |
dc.subject.emtree | Prematurity | en_US |
dc.subject.emtree | Prospective study | en_US |
dc.subject.emtree | Randomized controlled trial | en_US |
dc.subject.emtree | Sepsis | en_US |
dc.subject.emtree | Tertiary care center | en_US |
dc.subject.emtree | Total parenteral nutrition | en_US |
dc.subject.emtree | Incidence | en_US |
dc.subject.emtree | Infant | en_US |
dc.subject.emtree | Infant mortality | en_US |
dc.subject.emtree | Necrotizing enterocolitis | en_US |
dc.subject.emtree | Prematurity | en_US |
dc.subject.emtree | Sepsis | en_US |
dc.subject.emtree | Tertiary health care | en_US |
dc.subject.emtree | Time factor | en_US |
dc.subject.emtree | Treatment outcome | en_US |
Appears in Collections: | Scopus Web of Science |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Güney_vd_2017.pdf | 220.27 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License