1. Açık Erişim@BUU
  2. İndeksli Yayınlar
  3. Web of Science
Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/30340
Full metadata record
DC FieldValueLanguage
dc.date.accessioned2023-01-09T11:59:51Z-
dc.date.available2023-01-09T11:59:51Z-
dc.date.issued2017-04-10-
dc.identifier.citationTezcan, G. vd. (2017). ''Olea europaea leaf extract and bevacizumab synergistically exhibit beneficial efficacy upon human glioblastoma cancer stem cells through reducing angiogenesis and invasion in vitro''. Biomedicine and Pharmacotherapy, 90, 713-723.en_US
dc.identifier.issn0753-3322-
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2017.04.022-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0753332217307813-
dc.identifier.uri1950-6007-
dc.identifier.urihttp://hdl.handle.net/11452/30340-
dc.description.abstractPatients with glioblastoma multiforme (GBM) that are cancer stem-cell-positive (GSC [+]) essentially cannot benefit from anti-angiogenic or anti-invasive therapy. In the present study, the potential anti-angiogenic and anti-invasive effects of Olea europaea (olive) leaf extract (OLE) were tested using GSC (+) tumours. OLE (2 mg/mL) caused a significant reduction in tumour weight, vascularisation, invasiveness and migration (p = 0.0001, p < 0.001, p = 0.004; respectively) that was associated with reducing the expression of VEGFA, MMP-2 and MMP-9. This effect was synergistically increased in combination with bevacizumab. Therefore, our current findings may contribute to research on drugs that inhibit the invasiveness of GBM.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectResearch & experimental medicineen_US
dc.subjectPharmacology & pharmacyen_US
dc.subjectAngiogenesisen_US
dc.subjectGlioblastoma cancer stem cellen_US
dc.subjectInvasionen_US
dc.subjectMMP2en_US
dc.subjectMMP9en_US
dc.subjectOlea europaea leaf extracten_US
dc.subjectVEGFAen_US
dc.subjectAntiangiogenic therapiesen_US
dc.subjectMesenchymal transitionen_US
dc.subjectAntioxidant activityen_US
dc.subjectOlive oilen_US
dc.subjectOleuropeinen_US
dc.subjectExpressionen_US
dc.subjectPolyphenolsen_US
dc.subjectGata6en_US
dc.subjectProliferationen_US
dc.subjectMicrorna-153en_US
dc.subject.meshAngiogenesis inhibitorsen_US
dc.subject.meshBevacizumaben_US
dc.subject.meshCell lineen_US
dc.subject.meshTumoren_US
dc.subject.meshCell movementen_US
dc.subject.meshDrug synergismen_US
dc.subject.meshGlioblastomaen_US
dc.subject.meshHumansen_US
dc.subject.meshMatrix metalloproteinase 2tr_TR
dc.subject.meshMatrix metalloproteinase 9en_US
dc.subject.meshNeoplasm invasivenessen_US
dc.subject.meshNeoplastic stem cellsen_US
dc.subject.meshNeovascularization, pathologicen_US
dc.subject.meshOleaen_US
dc.subject.meshPlant extractsen_US
dc.subject.meshPlant leavesen_US
dc.subject.meshVascular endothelial growth factor Aen_US
dc.titleOlea europaea leaf extract and bevacizumab synergistically exhibit beneficial efficacy upon human glioblastoma cancer stem cells through reducing angiogenesis and invasion in vitroen_US
dc.typeArticleen_US
dc.identifier.wos000402471000087tr_TR
dc.identifier.scopus2-s2.0-85017569324tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nöroşirürji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.relation.bapOUAP(T) 2013/22, 2013en_US
dc.relation.bapHDP(T)-2016/14, 2016tr_TR
dc.contributor.orcid0000-0001-5472-9065tr_TR
dc.contributor.orcid0000-0002-1619-6680tr_TR
dc.contributor.orcid0000-0002-3820-424Xtr_TR
dc.contributor.orcid0000-0002-5956-8755tr_TR
dc.contributor.orcid0000-0001-7904-883Xtr_TR
dc.identifier.startpage713tr_TR
dc.identifier.endpage723tr_TR
dc.identifier.volume90tr_TR
dc.relation.journalBiomedicine and Pharmacotherapyen_US
dc.contributor.buuauthorTezcan, Gülçin-
dc.contributor.buuauthorTaşkapılıoğlu, Mevlut Özgür-
dc.contributor.buuauthorTunca, Berrin-
dc.contributor.buuauthorBekar, Ahmet-
dc.contributor.buuauthorDemirci, Hilal-
dc.contributor.buuauthorKocaeli, Hasan-
dc.contributor.buuauthorAksoy, Seçil Ak-
dc.contributor.buuauthorEgeli, Ünal-
dc.contributor.buuauthorCecener, Gülşah-
dc.contributor.buuauthorTolunay, Şahsine-
dc.contributor.researcheridAAI-1612-2021tr_TR
dc.contributor.researcheridAAH-1420-2021tr_TR
dc.contributor.researcheridABB-8161-2020tr_TR
dc.contributor.researcheridAAH-3843-2020tr_TR
dc.contributor.researcheridAAW-5254-2020tr_TR
dc.contributor.researcheridABI-6078-2020tr_TR
dc.contributor.researcheridAAP-9988-2020tr_TR
dc.identifier.pubmed28419967tr_TR
dc.subject.wosMedicine, research & experimentalen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ2en_US
dc.contributor.scopusid25650627600tr_TR
dc.contributor.scopusid25936798300tr_TR
dc.contributor.scopusid6602965754tr_TR
dc.contributor.scopusid6603677218tr_TR
dc.contributor.scopusid57193932262tr_TR
dc.contributor.scopusid6603500567tr_TR
dc.contributor.scopusid57193933334tr_TR
dc.contributor.scopusid55665145000tr_TR
dc.contributor.scopusid6508156530tr_TR
dc.contributor.scopusid6602604390tr_TR
dc.subject.scopusCancer Stem Cell; Insurance Markets; Operational Risken_US
dc.subject.emtreeAngiogenesis inhibitoren_US
dc.subject.emtreeBevacizumaben_US
dc.subject.emtreeGelatinase Aen_US
dc.subject.emtreeGelatinase Ben_US
dc.subject.emtreeOlea europaea extracten_US
dc.subject.emtreePlant extracten_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeVasculotropin Aen_US
dc.subject.emtreeAngiogenesis inhibitoren_US
dc.subject.emtreeBevacizumaben_US
dc.subject.emtreeGelatinase Aen_US
dc.subject.emtreeGelatinase Ben_US
dc.subject.emtreePlant extracten_US
dc.subject.emtreeVasculotropin Aen_US
dc.subject.emtreeAntiangiogenic activityen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCancer inhibitionen_US
dc.subject.emtreeCancer stem cellen_US
dc.subject.emtreeCell invasionen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDrug efficacyen_US
dc.subject.emtreeDrug potentiationen_US
dc.subject.emtreeGlioblastomaen_US
dc.subject.emtreeGlioblastoma cell lineen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreeIn vitro studyen_US
dc.subject.emtreeMigration inhibitionen_US
dc.subject.emtreeOlive treeen_US
dc.subject.emtreePlant leafen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeCancer stem cellen_US
dc.subject.emtreeCell motionen_US
dc.subject.emtreeChemistryen_US
dc.subject.emtreeDrug effectsen_US
dc.subject.emtreeDrug potentiationen_US
dc.subject.emtreeGlioblastomaen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeNeovascularization (pathology)en_US
dc.subject.emtreeOlive treeen_US
dc.subject.emtreePathologyen_US
dc.subject.emtreePlant leafen_US
dc.subject.emtreeTumor cell lineen_US
dc.subject.emtreeTumor invasionen_US
Appears in Collections:Scopus
Web of Science

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.