Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/30600
Title: Changes of inflammatory and oxidative stress biomarkers in dogs with different stages of heart failure
Authors: Rubio, Camila Peres
Tanaka, Ryou
Koch, Jorgen
Ceron, Jose Joaquin
Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Dahiliye Anabilim Dalı.
0000-0002-2849-1222
Sarıl, Ahmet
Kocatürk, Meriç
Yılmaz, Zeki
DQX-5263-2022
GGO-7900-2022
57202390224
36437200800
35944810500
Keywords: Veterinary sciences
Cytokines
Chemokines
Inflammation
Oxidative stress
Heart failure
Dogs
Mitral-valve disease
Total antioxidant capacity
Protein concentrations
Systemic inflammation
Paraoxonase 1
Left atrial
Serum
Cytokines
Markers
Volume
Issue Date: 10-Nov-2020
Publisher: BMC
Citation: Rubio, C. P. vd. (2020). "Changes of inflammatory and oxidative stress biomarkers in dogs with different stages of heart failure". BMC Veterinary Research, 16(1).
Abstract: BackgroundHeart failure (HF) is associated with changes in inflammatory and oxidative stress biomarkers. This study aimed to evaluate the changes of a panel of inflammatory and oxidative stress biomarkers in dogs with different stages of HF and its relation with the severity of the disease and echocardiographic changes. A total of 29 dogs with HF as a result of myxomatous mitral valve degeneration or dilated cardiomyopathy were included and classified as stage-A (healthy), B (asymptomatic dogs), C (symptomatic dogs) and D (dogs with end-stage HF) according to the ACVIM staging system. In these dogs an ecnhocardiographic examination was performed and cytokines, and inflammatory and oxidative stress markers were evaluated in serum.ResultsKC-like was significantly increased in dogs of stage-C (P<0.01) and -D (P<0.05) compared with stage-A and -B. Stage-D dogs showed significantly higher serum CRP and Hp (P<0.05) but lower serum antioxidant capacity (PON1, TEAC, CUPRAC, and thiol) compared to stage-A and -B (P<0.05). After the treatment, serum levels of CRP, Hp and KC-like decreased and serum antioxidant levels increased compared to their pre-treatment values. Left ventricular dimension and LA/Ao ratio correlated positively with CRP, MCP-1, and KC-like but negatively with PON1, GM-CSF, IL-7 and antioxidant biomarkers (P<0.01).ConclusionOur results showed that dogs with advanced HF show increases in positive acute-phase proteins and selected inflammatory cytokines such as KC-like, and decreases in antioxidant biomarkers, indicating that inflammation and oxidative stress act as collaborative partners in the pathogenesis of HF. Some of these biomarkers of inflammation and oxidative stress could have the potential to be biomarkers to monitor the severity of the disease and the effect of treatment.
URI: https://doi.org/10.1186/s12917-020-02650-7
https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-020-02650-7
http://hdl.handle.net/11452/30600
ISSN: 1746-6148
Appears in Collections:PubMed
Scopus
Web of Science

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