Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/30719
Title: Mixed ligand complexes of Co(II), Ni(II) and Cu(II) with quercetin and diimine ligands: Synthesis, characterization, anti-cancer and anti-oxidant activity
Authors: Ulukaya, Engin
Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü.
Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.
0000-0002-6729-7908
0000-0002-3127-742X
0000-0002-0026-7755
Gençkal, Hasene
Erkısa, Merve
Pınar, Alper
Şahin, Saliha
Arı, Ferda
AAH-2892-2021
57212275330
57126208900
15027401600
24376085300
Keywords: Flavonoid complexes
Quercetin
1
10-Phenanthroline
2
2 '-bipyridine
Cytotoxicity
Anti-cancer activity
Antioxidant activity
Mitochondria-mediated apoppsis
Cell-cycle arrest
Antitumor activities
Copper(II) complexes
Metal-complexes
II complexes
DNA-binding
Flavonoids
Activation
Derivatives
Biochemistry & molecular biology
Chemistry
Issue Date: 2-Dec-2019
Publisher: Springer
Citation: Gençkal, H. M. vd. (2020). "Mixed ligand complexes of Co(II), Ni(II) and Cu(II) with quercetin and diimine ligands: Synthesis, characterization, anti-cancer and anti-oxidant activity". Journal of Biological Inorganic Chemistry, 25(1), 161-177.
Abstract: In this work, mixed ligand complexes of Co(II) Ni(II) and Cu(II) were synthesized using quercetin and diimine (1,10-phenanthroline or 2,2 '-bipyiridine) ligands. The obtained Ni(II) and Co(II) complexes are new and the Cu(II) complexes are synthesized by different method from the literature. The characterization of complexes was performed by elemental analysis, thermogravimetric analysis, ESI-MS, UV-visible and infrared spectral analyses, magnetic susceptibility and molar conductivity measurements. It was found that quercetin, diimine and metal(II) ion form 1:1:1 complexes. Resulting data supported octahedral geometry for Ni(II) and Co(II) complexes and square pyramidal geometry for Cu(II) complexes. The proposed compositions are [Co(queH-1)Cl(phen)(H2O)]center dot 2H(2)O (1, queH = quercetin, phen = 1,10-phenanthroline), [Ni(queH-1)Cl(phen)(H2O)]center dot 2H(2)O (2), [Cu(queH-1)Cl(phen)]center dot 2.5H(2)O (3) and [Cu(queH-1)Cl(bpy)]center dot 2H(2)O (4, bpy = 2,2 '-bipyiridine). Antioxidant capacity and total phenolic content of complexes measured by Folin-Ciocalteu and ABTS methods. Anti-cancer effect of these compounds were tested against different cancer cells (A549, PC-3, HeLa and MCF-7). Apoptosis identified by the fluorescence imaging, caspase cleaved cytokeratin-18 and flow cytometry analysis (annexin V, caspase 3/7, mitochondria membrane potential and oxidative stress). As a result, Cu(II) complexes are more effective than the other compounds and Complex 3 is a promising anti-cancer compound against breast cancer MCF-7 and MDA-MB-231 cells (IC50 values are 2.4 and 5.4 mu M for 48 h, respectively). Flow cytometry analysis exhibited that Complex 3 caused apoptosis in MCF-7 cells. These results support that Complex 3 has anticancer activity and can be a potential anticancer agent especially in breast cancer.
URI: https://doi.org/10.1007/s00775-019-01749-z
https://link.springer.com/article/10.1007/s00775-019-01749-z
http://hdl.handle.net/11452/30719
ISSN: 0949-8257
1432-1327
Appears in Collections:PubMed
Scopus
Web of Science

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