1. Açık Erişim@BUU
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Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/30737
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dc.contributor.authorÖzgöz, Asuman-
dc.contributor.authorŞamlı, Murat-
dc.contributor.authorŞahin, Ahmet-
dc.contributor.authorİnce, Ümit-
dc.contributor.authorSağlıcan, Yeşim-
dc.date.accessioned2023-01-31T08:45:14Z-
dc.date.available2023-01-31T08:45:14Z-
dc.date.issued2016-07-07-
dc.identifier.citationÖzgöz, A. vd. (2017). ''Association of b7-h4 gene polymorphisms in urothelial bladder cancer''. Turkish Journal of Medical Sciences, 47(2), 443-446.tr_TR
dc.identifier.issn1300-0144-
dc.identifier.urihttps://doi.org/10.3906/sag-1603-54-
dc.identifier.uri1303-6165-
dc.identifier.urihttps://journals.tubitak.gov.tr/medical/vol47/iss2/12/-
dc.identifier.urihttp://hdl.handle.net/11452/30737-
dc.description.abstractBackground/aim: We aimed to study polymorphisms of the B7-H4 gene in order to evaluate a possible association in urothelial carcinoma, as it is highly expressed in cancer tissues. Materials and methods: In this study B7-H4 gene rs10754339, rs10801935, and rs3738414 SNPs were studied by PCR-RFLP method in paraffin-embedded tumor specimens from 62 urothelial carcinoma patients and in a control group including 30 patients without bladder cancer. Results: We detected that the rs10754339 polymorphism was more frequent in the cancer patients when compared with the control group (P < 0.05). Only the rs3738414 polymorphism showed a statistically significant difference in frequency between pathologic diagnostic groups. Conclusion: The rs10754339 AA genotype distribution was found to have a higher frequency whereas the rs3738414 AG genotype distribution was lower in the bladder cancer group (P < 0.05). None of the genotype distributions showed a significant difference from the control group for the rs10801935 polymorphism. We conclude that B7-H4 has the potential to be a useful prognostic marker in urothelial carcinoma.en_US
dc.language.isoenen_US
dc.publisherTÜBİTAKtr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAtıf Gayri Ticari Türetilemez 4.0 Uluslararasıtr_TR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGeneral & internal medicineen_US
dc.subjectBladder canceren_US
dc.subjectPolymorphismen_US
dc.subjectB7-H4 geneen_US
dc.subjectT-cell-activationen_US
dc.subjectB7 family-memen_US
dc.subjectBerbreast-canceren_US
dc.subjectImmunityen_US
dc.subjectExpressionen_US
dc.subjectCostimulationen_US
dc.subjectMoleculesen_US
dc.subjectLigandsen_US
dc.subject.meshAgeden_US
dc.subject.meshBiomarkers, tumoren_US
dc.subject.meshFemaleen_US
dc.subject.meshGene frequencyen_US
dc.subject.meshGenetic association studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshPolymorphism, single nucleotideen_US
dc.subject.meshPredictive value of testsen_US
dc.subject.meshReal-time polymerase chain reactionen_US
dc.subject.meshUrinary bladder neoplasmsen_US
dc.subject.meshUrotheliumen_US
dc.subject.meshV-set domain-containing T-cell activation inhibitor 1en_US
dc.titleAssociation of b7-h4 gene polymorphisms in urothelial bladder canceren_US
dc.typeArticleen_US
dc.identifier.wos000399829700012tr_TR
dc.identifier.scopus2-s2.0-85018778719tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Genetik Anabilim Dalı.tr_TR
dc.relation.bapOUAP(V) - 2013 /3tr_TR
dc.contributor.orcid0000-0002-8015-9032tr_TR
dc.identifier.startpage443tr_TR
dc.identifier.endpage446tr_TR
dc.identifier.volume47tr_TR
dc.identifier.issue2tr_TR
dc.relation.journalTurkish Journal of Medical Sciencesen_US
dc.contributor.buuauthorDinçel, Deniz-
dc.contributor.buuauthorBalcı, Faruk-
dc.contributor.buuauthorŞamlı, Hale-
dc.contributor.researcheridAAH-6192-2021tr_TR
dc.contributor.researcheridAAH-6488-2021tr_TR
dc.relation.collaborationYurt içitr_TR
dc.indexed.trdizinTrDizintr_TR
dc.identifier.pubmed28425229tr_TR
dc.subject.wosMedicine, general & internalen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ4en_US
dc.contributor.scopusid56607385000tr_TR
dc.contributor.scopusid16062981700tr_TR
dc.contributor.scopusid6507670789tr_TR
dc.subject.scopusB7 Antigens; Tumor Escape; Canceren_US
dc.subject.emtreeTumor markeren_US
dc.subject.emtreeV set domain containing T cell activation inhibitor 1en_US
dc.subject.emtreeVTCN1 protein, humanen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeB7 H4 geneen_US
dc.subject.emtreeCancer diagnosisen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGeneen_US
dc.subject.emtreeGene frequencyen_US
dc.subject.emtreeGenetic associationen_US
dc.subject.emtreeGenotypeen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreePolymerase chain reactionen_US
dc.subject.emtreeRestriction fragment length polymorphismen_US
dc.subject.emtreeSingle nucleotide polymorphismen_US
dc.subject.emtreeSmokingen_US
dc.subject.emtreeTransitional cell carcinomaen_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeBladder tumoren_US
dc.subject.emtreeGenetic association studyen_US
dc.subject.emtreeGeneticsen_US
dc.subject.emtreePathologyen_US
dc.subject.emtreePhysiologyen_US
dc.subject.emtreePredictive valueen_US
dc.subject.emtreeReal time polymerase chain reactionen_US
dc.subject.emtreeSingle nucleotide polymorphismen_US
dc.subject.emtreeUrotheliumen_US
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