Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/31723
Title: Lipid profile in type 2 diabetic patients with new dapagliflozin treatment; actual clinical experience data of six months retrospective lipid profile from single center
Authors: Çalapkulu, Murat
Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri/İç Hastalıkları Bölümü.
Cander, Soner
Gül, Özen Öz
Ersoy, Canan
AAI-1005-2021
AAH-8861-2021
25027068600
26040787100
6701485882
Keywords: Endocrinology & metabolism
Type 2 diabetes
Dapagliflozin
Lipid profile
Ldl
Total cholesterol
Triglyceride
Glycemic control
Therapy
Issue Date: 17-Jan-2019
Publisher: Elsevier Science
Citation: Çalapkulu, M. vd. (2019). ''Lipid profile in type 2 diabetic patients with new dapagliflozin treatment; actual clinical experience data of six months retrospective lipid profile from single center''. Diabetes & Metabolic Syndrome-Clinical Research & Reviews, 13(2), 1031-1034.
Abstract: Introduction: Dapagliflozin is a sodium-glucose cotransporter 2 inhibitor that improves glycemic control in patients with type II diabetes mellitus which increasing urinary glucose excretion. With numerous controlled experimental studies of dapagliflozin, evaluation of real-life data after entry into clinical practice is an important condition. In our study, the effects of dapagliflozin (10 mg) on lipid profile were investigated retrospectively. Methods: A total of thirty-one type 2 diabetic patients with HbA1c level between 6,5% and 13%, aged 45 -80 years and whose body mass index higher than 20 kg/m(2) were enrolled to the study. Data before dapagliflozin treatment and three and six months results were recorded. Results: Dapagliflozin reduced HbA1c levels by 0,9% at 3 months and 0,79% at 6 months. Total cholesterol level decreased 17,6 mg/dl, LDL cholesterol level decreased 13,4 mg/dl and triglyceride level by 25.9mg/dl at the 6th months and it is observed that there is no serious side effect on the usage for 6 months. Conclusion: There are conflicting results about the effect of SGLT2 inhibitors on the lipid profile in the literature. According to our data, dapagliflozin has positive effects on lipid profile as weight and glycemic control and it is well tolerated. Therefore, dapagliflozin therapy is beneficial because of the positive change in lipid profile and weight loss in diabetic patients with overweight and hyperlipidemia.
URI: https://doi.org/10.1016/j.dsx.2019.01.016
https://www.sciencedirect.com/science/article/pii/S1871402118306313
http://hdl.handle.net/11452/31723
ISSN: 1871-4021
1878-0334
Appears in Collections:PubMed
Scopus
Web of Science

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