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Title: | Histamine restores hemorrhage induced hypotension by activating cholinergic neurons in nucleus tractus solitarius |
Authors: | Uludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı. Uludağ Üniversitesi/Veteriner Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı. 0000-0002-5600-8162 Altınbaş, Burçin Güvenç, Gökçen Erkan, Leman G. İlhan, Tuncay Niaz, Nasir Yalçın, Murat AAG-6956-2021 AAH-8859-2021 AAR-6815-2021 AAC-4975-2022 55356919300 56529426800 56529371200 16549312600 57060367600 57192959734 |
Keywords: | Neurosciences & neurology Histamine Nucleus tractus solitarius Central cholinergic system Cardiovascular system Hemorrhagic hypotension Endogenous central histamine Modulate acetylcholine-release Dual-probe microdialysis Freely moving rat Induced reversal Cardiovascular regulation Thromboxane A(2) Arachidonic-acid Injected melittin Ventral striatum |
Issue Date: | 30-Jun-2016 |
Publisher: | Elsevier |
Citation: | Altınbaş, B. vd. (2016). "Histamine restores hemorrhage induced hypotension by activating cholinergic neurons in nucleus tractus solitarius". Brain Research, 1649(Part A), 132-140. |
Abstract: | The purpose of the current study is to investigate the functional connections between the central histaminergic and cholinergic systems at NTS level in hypotensive condition. Experiments were carried out in male Wistar Albino rats. The hypotension was achieved by withdrawing a total volume of 1.5 ml blood/100 g bodyweight over a period of 10 min. A microdialysis study was performed in NTS area to measure extracellular ACh and Ch levels. The hemorrhage produced a severe and long-lasting decrease in mean arterial blood pressure (MAP) and increase in extracellular ACh and Ch levels in NTS. Administration of histamine intracerebroventricularly (i.c.v.) or into the NTS reversed the hemorrhagic hypotension by increasing MAP and heart rate. I.c.v. injection of histamine also caused the additional increase in extracellular ACh and Ch levels. Moreover, central histamine injection augmented intracytoplasmic AChE immunoreactivity in NTS. These changes were completely blocked by histaminergic H1 receptor antagonist chlorpheniramine, but histaminergic H2 receptor blocker ranitidine and histaminergic H3/H4 receptor antagonist thioperamide failed to produce these effects. In conclusion, these findings are interpreted that brain histaminergic H1 receptor activation by central histamine injection may promote cholinergic stimulation in the NTS and subsequently reverses the hypotension. |
URI: | https://doi.org/10.1016/j.brainres.2016.06.047 https://www.sciencedirect.com/science/article/pii/S0006899316304723 http://hdl.handle.net/11452/32207 |
ISSN: | 0006-8993 1872-6240 |
Appears in Collections: | Scopus Web of Science |
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