Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/32671
Title: Analysis of liver function test abnormalities in kidney transplant recipients: 7 year experience
Authors: Dizdar, Oğuzhan Sıtkı
Coşkun, Banu Demet Özel
Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Nefroloji Bilim Dalı.
0000-0002-0710-0923
Ersoy, Alparslan
Aksoy, Savaş
Yıldız, Abdülmecit
J-1232-2013
AAH-5054-2021
35612977100
57192690937
56256977500
Keywords: General & internal medicine
Complication
Cytomegalovirus
Hepatotoxicity
Mycophenolatemofetil
Kidney transplantation
Renal-allograft recipients
Graft-rejection
Cyclosporine
Sirolimus
Hepatotoxicity
Tacrolimus
Therapy
Hepatitis
Drugs
Issue Date: 25-Sep-2016
Publisher: Professional Medical Publications
Citation: Dizdar, O. S. vd. (2016). "Analysis of liver function test abnormalities in kidney transplant recipients: 7 year experience". Pakistan Journal of Medical Sciences, 32(6), 1330-1335.
Abstract: Objective: Immunosuppressive drugs, antimicrobial agents and infectious complications may cause liver function test abnormalities (LFTA) in kidney transplant recipients (KTR). The objectives of this study were to identify the outcome of (LFTA). To identify the risk factors affecting development and severity of hepatotoxicity in KTR. Methods: We retrospectively evaluated the medical records of KTR. Hepatotoxicity attacks were defined as impairment in liver function tests that was responsive to drug dose reduction or discontinuation, or treatment of specific causes such as infectious complications. Results: One hundred-fifty-six episodes of hepatotoxicity occurred in 107 patients in 281 KTR, with an incidence of 38%. Patients with hepatotoxicity episodes had a high total mortality rate, higher incidence of positive pre-transplant cytomegalovirus (CMV) IgM test, higher creatinine values during the first month post-transplant, underwent additional acute rejection episodes, and received fewer cyclosporin A based ID. Only positive CMV IgM testing was identified as a significant independent risk factor for hepatotoxicity in our multiple analysis. Mycophenolatemofetil (MMF) related hepatotoxicity was the most common cause of drug related LFTA. Conclusions: Patients with LFTA can have significant complications. Pre-transplant positive CMV IgM tests predispose transplant recipients to the development of LFTA during the post-transplant period. MMF can be a serious hepatotoxic drug.
URI: https://doi.org/10.12669/pjms.326.10725
https://pjms.com.pk/index.php/pjms/article/view/10725
http://hdl.handle.net/11452/32671
ISSN: 1682-024X
Appears in Collections:Scopus
Web of Science

Files in This Item:
File Description SizeFormat 
Ersoy_vd_2016_PDF.pdf279.65 kBAdobe PDFThumbnail
View/Open


This item is licensed under a Creative Commons License Creative Commons