Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/34256
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dc.contributor.authorDemir, Nesrin-
dc.contributor.authorÇağan, Eren-
dc.date.accessioned2023-10-09T08:31:13Z-
dc.date.available2023-10-09T08:31:13Z-
dc.date.issued2020-11-
dc.identifier.citationHız, P. vd. (2020). "Roles of novel IL-1 family (IL-36, IL-37, and IL-38) members in chronic brucellosis". Cytokine, 135.en_US
dc.identifier.issn1043-4666-
dc.identifier.issn1096-0023-
dc.identifier.urihttps://doi.org/10.1016/j.cyto.2020.155211-
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/32736334/-
dc.identifier.urihttp://hdl.handle.net/11452/34256-
dc.description.abstractThe secretion of interleukin (IL)-1 family cytokines is one of the most potent and earliest pro-inflammatory responses triggered by brucellosis. However, the roles of the most recently discovered IL-1 family members, IL-36, IL-37, and IL-38, in the transition into the chronic form of brucellos is remain largely unknown. Therefore, in this study, the roles of IL-36, IL-37, and IL-38 in brucella infections and their effects on the transition from the acute to chronic form of the disease were investigated. Using peripheral blood samples from 40 patients with acute brucellosis, 40 patients with chronic brucellosis, and 40 healthy control subjects, we analysed the serum concentrations of secreted IL-36, IL-37, and IL-38 using ELISA. The findings were confirmed by using RT-qPCR to analyse the mRNA levels of the genes encoding IL-36, IL-37, and IL-38 in peripheral blood mononuclear cells (PBMCs) from 10 randomly selected patients from each of the three groups. Our results showed that serum IL-37 (p < 0.001) and IL-38 (p < 0.001) concentrations were lower in patients with brucellosis than in the healthy controls. In addition, serum IL-37 and IL-38 concentrations were higher in the chronic patient group than in the acute patient group. The mRNA expression levels of IL-37 and IL1F10, genes that encode IL-38, did not affect serum cytokine secretion levels. This result suggests that the high secretion levels of IL-37 and IL-38 may be related to the progression into the chronic form of brucellosis. Our findings will aid in clarifying the mechanism of the transition of brucellosis from the acute to the chronic form of the disease.en_US
dc.language.isoenen_US
dc.publisherAcademic Pressen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrucellosisen_US
dc.subjectChronicen_US
dc.subjectAcuteen_US
dc.subjectIL-38en_US
dc.subjectIL-37en_US
dc.subjectIL-36en_US
dc.subjectExpressionen_US
dc.subjectIdentificationen_US
dc.subjectInterleukin-38en_US
dc.subjectGeneen_US
dc.subjectBiochemistry & molecular biologyen_US
dc.subjectImmunologyen_US
dc.subjectCell biologyen_US
dc.subject.meshCells, cultureden_US
dc.subject.meshSerumen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInterleukin-1en_US
dc.subject.meshInterleukinsen_US
dc.subject.meshLeukocytesen_US
dc.subject.meshMononuclearen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshCultureden_US
dc.subject.meshAdultsen_US
dc.subject.meshBrucellosisen_US
dc.subject.meshChronic diseaseen_US
dc.titleRoles of novel IL-1 family (IL-36, IL-37, and IL-38) members in chronic brucellosisen_US
dc.typeArticleen_US
dc.identifier.wos000572835200021tr_TR
dc.identifier.scopus2-s2.0-85088654333tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Diş Hekimliği Fakültesi/Temel Bilimler Bölümü/Temel Bilimler Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri/İmmünoloji Anabilim Dalı.tr_TR
dc.relation.bapDDP(T)-2017/13tr_TR
dc.contributor.orcid0000-0001-8399-8942tr_TR
dc.contributor.orcid0000-0003-0463-6818tr_TR
dc.contributor.orcid0000-0001-7625-9148tr_TR
dc.contributor.orcid0000-0002-5956-8755tr_TR
dc.identifier.volume135tr_TR
dc.relation.journalCytokineen_US
dc.contributor.buuauthorHız, Pınar-
dc.contributor.buuauthorKanbur, Ertan-
dc.contributor.buuauthorAkalın, Halis-
dc.contributor.buuauthorPashazadeh, Mehrdat-
dc.contributor.buuauthorBal, Salih Haldun-
dc.contributor.buuauthorOral, Haluk Barbaros-
dc.contributor.buuauthorBudak, Ferah-
dc.contributor.buuauthorTezcan, Gülçin-
dc.contributor.researcheridEZA-7505-2022tr_TR
dc.contributor.researcheridAAU-8952-2020tr_TR
dc.contributor.researcheridDLI-4479-2022tr_TR
dc.contributor.researcheridHJY-9001-2023tr_TR
dc.contributor.researcheridK-7285-2012tr_TR
dc.contributor.researcheridF-4657-2014tr_TR
dc.contributor.researcheridAAH-3843-2020tr_TR
dc.relation.collaborationSanayitr_TR
dc.identifier.pubmed32736334tr_TR
dc.subject.wosBiochemistry & molecular biologyen_US
dc.subject.wosImmunologyen_US
dc.subject.wosCell biologyen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ3en_US
dc.contributor.scopusid57189853087tr_TR
dc.contributor.scopusid57218292727tr_TR
dc.contributor.scopusid57207553671tr_TR
dc.contributor.scopusid48461762300tr_TR
dc.contributor.scopusid57191480128tr_TR
dc.contributor.scopusid7004498001tr_TR
dc.contributor.scopusid6701913697tr_TR
dc.contributor.scopusid25650627600tr_TR
dc.subject.scopusPustulosis palmoplantaris ; Cytokines ; Interleukin-1 Receptor Accessory Proteinen_US
dc.subject.emtreeCytokineen_US
dc.subject.emtreeInterleukin derivativeen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeInterleukin 36en_US
dc.subject.emtreeInterleukin 38en_US
dc.subject.emtreeInterleukin 37en_US
dc.subject.emtreeMessenger RNAen_US
dc.subject.emtreeInterleukin 1en_US
dc.subject.emtreeIL37 proteinen_US
dc.subject.emtreeIL-38 proteinen_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBrucella abortusen_US
dc.subject.emtreeBrucellosisen_US
dc.subject.emtreeChronic brucellosisen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeReleaseen_US
dc.subject.emtreeDisease exacerbationen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGene expressionen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreeIL 37 geneen_US
dc.subject.emtreeIL1F10 geneen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreePeripheral blood mononuclearen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProtein blood levelen_US
dc.subject.emtreeBlooden_US
dc.subject.emtreeCell cultureen_US
dc.subject.emtreeChronic diseaseen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeMiddle ageen_US
dc.subject.emtreeMononuclear cellen_US
dc.subject.emtreeSerumen_US
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