Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/34699
Title: Methotrexate intoxication: Beyond the adverse events
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.
0000-0003-0298-4157
Dalkılıç, Ediz
Coşkun, Belkıs Nihan
Yağız, Burcu
Tufan, Ayşe Nur
Ermurat, Selime
Pehlivan, Yavuz
AAG-7155-2021
ABE-4424-2022
AAG-8227-2021
6506739457
55646165400
57203458191
56076552900
55371331300
13205593600
Keywords: Rheumatology
Methotrexate
Methotrexate toxicity
Renal insufficiency
Low-dose methotrexate
Rheumatoid-arthritis
Acid supplementation
Induced pancytopenia
Folinic acid
Toxicity
Therapy
Issue Date: Aug-2018
Publisher: Wiley
Citation: Dalkılıç, E. vd. (2018). ''Methotrexate intoxication: Beyond the adverse events''. International Journal of Rheumatic Diseases, 21(8), 1557-1562.
Abstract: Aim: Methotrexate (MTX) is the first-line disease-modifying antirheumatic drug in rheumatoid arthritis (RA). However, this anchor may cause some side effects that may range from nausea to mortality. The clinical features of MTX toxicity are under-researched. In this study, we aimed to find out the potential predisposing factors and outcomes of the MTX toxicity (n = 31). Methods: The data were collected from 31 patients whose ages ranged from 25 to 81 years, who were suffering from immune-mediated inflammatory diseases and major MTX-related toxicity. Results: Out of 31 patients, six (19.4%) used MTX every day, and 13 (41.9%) patients had renal insufficiency who were admitted to the hospital because of mucositis (90.3%) and fever (71%). While using MTX, 27 patients (87.1%) were discharged after the treatment and four patients (12.9%) died. Conclusions: Although MTX has high efficacy for the toxicity ratio, wrong use and dosage of MTX may be harmful to patients. Thus, patients should be informed about the proper use of MTX.
URI: https://doi.org/10.1111/1756-185X.13339
https://onlinelibrary.wiley.com/doi/10.1111/1756-185X.13339
http://hdl.handle.net/11452/34699
ISSN: 1756-1841
1756-185X
Appears in Collections:Scopus
Web of Science

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