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Bu öğeden alıntı yapmak, öğeye bağlanmak için bu tanımlayıcıyı kullanınız: http://hdl.handle.net/11452/20899
Başlık: The effects of azone and capsaicin on the permeation of naproxen through human skin
Yazarlar: Degim, İ. Tuncer
Uslu, A.
Hadgraft, Jonathan
Atay, T.
Cevheroğlu, S.
Uludağ Üniversitesi/Tıp Fakültesi.
0000-0002-2306-5451
Akay, Cemal
AAA-7011-2021
Anahtar kelimeler: Azone
Capsaicin
Naproxen
Penetration enhancers
Skin absorption
Pharmacology & pharmacy
Yayın Tarihi: 1-Mar-1999
Yayıncı: Elsevier Science BV
Atıf: Degim, İ. T. vd. (1999). "The effects of azone and capsaicin on the permeation of naproxen through human skin". International Journal of Pharmaceutics, 179(1), 21-25.
Özet: The permeation of naproxen through excised human skin and isolated perfused rabbit ear skin has been determined. It was found that both Atone and capsaicin enhanced the permeation with an enhancement ratio of up to 4-fold. The magnitudes of the effect were similar in human and rabbit skin. The permeation of naproxen from a saturated solution of the drug through skin pre-treated with Atone was similar to that from a commercial preparation (Naprosyn). In the perfused rabbit ear experiments the presence of capsaicin had no effect on the vasodilatation of the blood vessels, inferring that the penetration enhancement was a direct result of capsaicin influencing the barrier function of the skin. Structural similarities between Atone and capsaicin were seen using molecular graphics.
URI: https://doi.org/10.1016/S0378-5173(98)00353-6
https://www.sciencedirect.com/science/article/pii/S0378517398003536
http://hdl.handle.net/11452/20899
ISSN: 0378-5173
Koleksiyonlarda Görünür:Web of Science

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