1. Açık Erişim@BUU
  2. İndeksli Yayınlar
  3. Web of Science
Bu öğeden alıntı yapmak, öğeye bağlanmak için bu tanımlayıcıyı kullanınız: http://hdl.handle.net/11452/20962
Başlık: Clinical investigation of methotrexate in the treatment of ankylosing spondylitis
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi.
Altan, Lale
Bingöl, Ümit
Karakoç, Yüksel
Yurtkuran, Merih
Yurtkuran, Mustafa
Aydıner, Saadet
AAH-1652-2021
Anahtar kelimeler: Rheumatology
Second-line drugs
Spondylitis
Methotrexate
Rheumatoıd-arthritis
Functional index
Long-term
Sulfasalazine
Therapy
Placebo
Trial
Yayın Tarihi: 2001
Yayıncı: Taylor & Francis
Atıf: Altan, L. vd. (2001). "Clinical investigation of methotrexate in the treatment of ankylosing spondylitis". Scandinavian Journal of Rheumatology, 30(5), 255-259.
Özet: Objectives: To investigate the efficacy and possible side effects of Methotrexate (MTX) treatment in patients with ankylosing spondylitis. Methods: A total of 51 patients with a diagnosis of AS according to NewYork criteria were randomly distributed into 2 groups. In Group I (n=25) only Naproxen (1000mg/day) and in Group II (n=26) oral MTX (7.5mg/week) combined with Naproxen were given for 12 months. The patients were evaluated at 3, 6, and 12 months after the start of the treatment according to a number of clinical parameters using objective and subjective variables. Data were analysed using ki-square and Mann-Whitney U tests. Results and conclusions: The comparison of the values using the percent changes and difference scores with respect to pretreatment values showed significant improvement in the "global evaluation of the physician" in Group II compared to Group I while no other parameter was found to be significantly different between the two groups. Those results have led us to conclude that a combination of MTX with Naproxen did not prove to be superior to Naproxen-alone treatment in terms of statistical significance. Further trials with MTX employing larger doses and different patient populations, mainly comprised of peripheral arthritis are necessary for delineation of the role of MTX in AS treatment
URI: https://doi.org/10.1080/030097401753180318
https://www.tandfonline.com/doi/abs/10.1080/030097401753180318
http://hdl.handle.net/11452/20962
ISSN: 0300-9742
Koleksiyonlarda Görünür:Web of Science

Bu öğenin dosyaları:
Bu öğeyle ilişkili dosya bulunmamaktadır.
Tüm Öğe Kaydını Göster İstatistikler


Bu öğe kapsamında lisanslı Creative Commons License Creative Commons