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Başlık: Oxidative stress and serum paraoxonase activity in experimental hypothyroidism: effect of vitamin E supplementation
Yazarlar: Taş, Sibel
Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.
0000-0002-2593-7196
Sarandol, Emre
Taş, Sibel
Dirican, Melahat
Serdar, Zehra
ABE-1716-2020
ABE-6873-2020
Anahtar kelimeler: Low-density-lipoprotein
Protection
Lipid-peroxidation
Subclinical hypothyroidism
Antioxidant defense
Damage
Rat
Arylesterase
Glutathione
Ldl
Hypothyroidism
Vitamin E
Oxidative stress
Rat
Paraoxonase
Biochemistry & molecular biology
Cell biology
Yayın Tarihi: 2005
Yayıncı: Wiley
Atıf: Sarandol, E. vd. (2005). "Oxidative stress and serum paraoxonase activity in experimental hypothyroidism: effect of vitamin E supplementation". Cell Biochemistry and Function, 23(1), 1-8.
Özet: Thyroid hormones are associated with the oxidative and antioxidative status of the organism. Since data on the oxidative status of hypothyroidism are limited and controversial, we investigated the oxidant and antioxidant status and serum paraoxonase/arylesterase activities in propylthiouracil-induced hypothyroidism and examined the effect of vitamin E supplementation on this experimental model. Forty male Sprague Dawley rats were randomly divided into four groups (group 1, control; group 2, control + vitamin E; group 3, propylthiouracil; group 4, propylthiouracil + vitamin E). Plasma, red blood cell, liver, heart and skeletal muscle malondialdehyde levels were increased in the propylthiouracil-treated group compared with the control rats and were decreased in propylthiouracil + vitamin E group compared with the propylthiouracil-treated group. Vitamin E supplementation also significantly increased liver and kidney reduced glutathione levels in propylthiouracil treated animals. Serum paraoxonase and arylesterase activities were decreased in propylthiouracil treated group and vitamin E supplementation caused significant increase in serum paraoxonase activity compared with the propylthiouracil-treated rats. These findings suggest that hypothyroidism is accompanied with increased oxidative stress and vitamin E supplementation exerts beneficial effects on this situation.
URI: https://doi.org/10.1002/cbf.1119
https://onlinelibrary.wiley.com/doi/abs/10.1002/cbf.1119
http://hdl.handle.net/11452/20991
ISSN: 0263-6484
Koleksiyonlarda Görünür:Web of Science

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