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http://hdl.handle.net/11452/21221
Başlık: | Fetal substantia nigra grafts-effect on dopamine receptors in the rat corpus striatium |
Yazarlar: | Knowles, W. D. Özmen, Tolga Uludağ Üniversitesi/Tıp Fakültesi/Beyin Cerrahisi Anabilim Dalı. Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı. Korfalı, Ender Ulus, Hakkı İ. Uysal, Sait D-5340-2015 |
Anahtar kelimeler: | General & internal medicine Substantia nigra Animal experiment Article Brain graft Corpus striatum Fetusat Nonhuman Rat Nonhuman |
Yayın Tarihi: | 1989 |
Yayıncı: | Cleveland Clinic |
Atıf: | Korfalı, E. vd. (1989). ''Fetal substantia nigra grafts-effect on dopamine receptors in the rat corpus striatium''. Cleveland Clinic Journal of Medicine, 56(3), 259-262. |
Özet: | Effects of fetal substantia nigra grafts on the dopamine receptors in the corpus striatum in rats were investigated after the destruction of the nigrostriatal dopaminergic pathways with intraventricular 6-hydroxydopamine injections. The expected dopamine receptor denervation supersensitivity was demonstrated by a 53.7% increase of [3H]spiroperidol binding in rats with sham grafts compared with normal control-group rats. In contrast, rats with grafts showed a significant reduction of supersensitivity, with a 25% decrease in binding to the graft-bearing caudate when compared with the sham-graft group. A nonsignificant 15% decrease in binding on the nongrafted side was also observed. The fetal substantia nigra grafts thus reduced the denervation supersensitivity toward a normal level. |
URI: | https://doi.org/10.3949/ccjm.56.3.259 https://pubmed.ncbi.nlm.nih.gov/2568188/ http://hdl.handle.net/11452/21221 |
ISSN: | 0891-1150 |
Koleksiyonlarda Görünür: | Web of Science |
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