Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/21463
Title: Interleukin-10 (IL-10) gene polymorphism as a potential host susceptibility factor in tuberculosis
Authors: Baştürk, Bilkay
Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Beyin Cerrahisi Anabilim Dalı.
0000-0002-4803-8206
0000-0003-0463-6818
Oral, Haluk B.
Bekar, Ahmet
Budak, Ferah
Akalın, Halis
Uzaslan, Esra Kunt
Ege, Ercüment
Ener, Beyza
Göral, Güher
F-4657-2014
AAI-1004-2021
AAG-8523-2021
K-7285-2012
AAU-8952-2020
Keywords: Biochemistry & molecular biology
Interferon-gamma gene
Cell biology
Mycobacterium-tuberculosis
Immunology
Online databases
Tuberculosis
Pulmonary tuberculosis
PCR-SSP
Human-disease
Genotyping
Ifn-gamma
Cytokine
Dendritic cells
Infection
1ST intron
Single nucleotide polymorphism
Issue Date: 2006
Publisher: Academic Press Ltd-Elsevier Science Ltd
Citation: Oral, H. B. vd. (2006). ''Interleukin-10 (IL-10) gene polymorphism as a potential host susceptibility factor in tuberculosis''. Cytokine, 35(3-4), 143-147.
Abstract: Several genes encoding for different cytokines may play crucial roles in host susceptibility to tuberculosis (TB), since the cytokine production capacity varies among individuals and depends on the cytokine gene polymorphism. The association of the cytokine gene polymorphisms with the development of TB was investigated in this study. DNA samples were obtained from a Turkish population of 81 patients with the different clinical forms of TB, and 50 healthy control subjects. All genotyping (IL-6, IL-10, IFN-gamma, TGF-beta and TNF-alpha) experiments were performed using sequence-specific primers PCR (PCR-SSP). Analysis of allete frequencies showed that IL-10 - 1082 G allele frequency was significantly more common in TB patients than healthy controls (37.7% vs 23.0%, p: 0.0 14). No statistically significant differences were observed betwe\en the different clinical forms of the disease. These results suggest that the polymorphisms in IL-10 gene may affect susceptibility to TB and increase risk of developing the disease. To confirm the biological significance of our results, further studies should be performed on other population groups. (c) 2006 Elsevier Ltd. All rights reserved.
URI: https://doi.org/10.1016/j.cyto.2006.07.015
https://www.sciencedirect.com/science/article/pii/S1043466606002225
http://hdl.handle.net/11452/21463
ISSN: 1043-4666
Appears in Collections:Scopus
Web of Science

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