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Başlık: Choline increases serum insulin in rat when injected intraperitoneally and augments basal and stimulated aceylcholine release from the rat minced pancreas in vitro
Yazarlar: Taga, Yavuz
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı.
İlçöl, Yeşim Özarda
Gürün, Mine Sibel
Ulus, İsmail Hakkı
AAL-8873-2021
D-5340-2015
AAG-8716-2019
55665181500
55664349700
7004271086
Anahtar kelimeler: Biochemistry & molecular biology
Animalia
Staphylococcus phage 3A
Precursor
Acetylcholine
Parasympathetic
Muscarinic reseptors
Nicotinic receptor
Muscarinic receptor subtypes
Islet hormone-secretion
Acetylcholine-release
Conscious rats
Tyrosine-hydroxylase
Glucagon-secretion
Brain
Citicoline
Striatum
Disease
Yayın Tarihi: Mar-2003
Yayıncı: Blackwell Publishing
Atıf: İlçöl, Y.Ö. vd. (2003). “Choline increases serum insulin in rat when injected intraperitoneally and augments basal and stimulated aceylcholine release from the rat minced pancreas in vitro”. European Journal of Biochemistry, 270(5), 991-999.
Özet: Intraperitoneal injection of choline (30-90 mg.kg(-1) ) produced a dose-dependent increase in serum insulin, glucose and choline levels in rats. The increase in serum insulin induced by choline (90 mg.kg(-1) ) was blocked by pretreatment with the muscarinic acetylcholine receptor antagonists, atropine (2 mg.kg(-1) ), pirenzepine (2 mg.kg(-1) ) and 4-diphenylacetoxy-N -methylpiperidine (2 mg.kg(-1) ) or the ganglionic nicotinic receptor antagonist, hexamethonium (15 mg.kg(-1) ). The effect of choline on serum insulin and glucose was enhanced by oral glucose administration (3 g.kg(-1) ). Choline administration was associated with a significant (P < 0.001) increase in the acetylcholine content of pancreatic tissue. Choline (10-130 mum) increased basal and stimulated acetylcholine release but failed to evoke insulin release from the minced pancreas at considerably higher concentrations (0.1-10 mm). Hemicholium-3, a choline uptake inhibitor, attenuated the increase in acetylcholine release induced by choline augmentation. Choline (1-32 mm) inhibited [(3) H]quinuclidinyl benzilate binding to the muscarinic receptors in the pancreatic homogenates. These data show that choline, a precursor of the neurotransmitter acetylcholine, increases serum insulin by indirectly stimulating peripheral acetylcholine receptors through the enhancement of acetylcholine synthesis and release.
URI: https://doi.org/10.1046/j.1432-1033.2003.03472.x
https://febs.onlinelibrary.wiley.com/doi/full/10.1046/j.1432-1033.2003.03472.x
http://hdl.handle.net/11452/21571
ISSN: 0014-2956
Koleksiyonlarda Görünür:Scopus
Web of Science

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