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Başlık: Changes of plasma free choline and choline-containing compounds' concentrations and choline loss during hemodialysis in ESRD patients
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
Özarda, Yeşim
Dilek, Kamil
Yurtkuran, Mustafa Abbas
Ulus, İsmail Hakkı
AAL-8873-2021
D-5340-2015
55665181500
56005080200
7003389525
7004271086
Anahtar kelimeler: Choline
Sphingomyelin
Phosphocholine
Phosphatidylcholine
End stage renal disease
Hemodialysis
Rat Corpus Striatum
Acetylcholine-release
Parenteral-nutrition
Tyrosine-hydroxylase
Brain phospholipids
Deficiency
Cytidine
Neurons
Liver
Yayın Tarihi: May-2002
Yayıncı: Pergamon-Elsevier Science
Atıf: Özarda, Y. vd. (2002). "Changes of plasma free choline and choline-containing compounds' concentrations and choline loss during hemodialysis in ESRD patients". Clinical Biochemistry , 35(3), 233-239.
Özet: Objectives: This study was undertaken to determine the changes in plasma free choline and choline-containing compounds in end stage renal disease (ESRD) and to determine if they were lost into the dialysate during hemodialysis. Design and methods: Plasma and dialysate free choline, phosphocholine and phospholipid, phosphatidylcholine-, sphingomyelin-bound choline were measured before, during and after hemodialysis. Results: Plasma free and bound choline concentrations (mean +/- standard error of the mean) were 12.9 +/- 0.6 and 2697 +/- 57 muM or 37.3 +/- 0.9 and 2792 +/- 98 muM in controls or in ESRD patients, respectively. Free choline concentrations were correlated (r = 0.598 p < 0.001) with the time the patients were subjected to hemodialysis. Plasma free choline and phosphocholine concentrations a-re decreased by a total of -8.1 +/- 0.6 μmol/L and -88 +/- 8 μmol/L, respectively: phospholipid- phosphatidylcholine- and sphingomyelin-bound choline are increased, during hemodialysis. Patients lost about 350 μmoles of choline into the dialysate during hemodialysis. Conclusion: Plasma free choline concentrations are elevated in ESRD. and a considerable amount of choline is lost into the hemodialysate.
URI: https://doi.org/10.1016/S0009-9120(02)00298-9
https://www.sciencedirect.com/science/article/pii/S0009912002002989
http://hdl.handle.net/11452/21689
ISSN: 0009-9120
Koleksiyonlarda Görünür:Scopus
Web of Science

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