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Başlık: The expression frequency of common fragile sites and genetic predisposition to colon cancer
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.
0000-0002-1619-6680
Tunca, Berrin
Egeli, Ünal
Zorluoğlu, Abdullah
Yılmazlar, Tuncay
Yerci, Ömer
Kızıl, Ayhan
ABI-6078-2020
Anahtar kelimeler: Oncology
Genetics & heredity
Cell lung-cancer
Short arm
Breast-cancer
Chromosome breakpoints
Colorectal-cancer
Fhit gene
Heterozygosity
Lymphocytes
Aphidicolin
Association
Yayın Tarihi: 2000
Yayıncı: Elsevier Science
Atıf: Tunca, B. vd. (2000). "The expression frequency of common fragile sites and genetic predisposition to colon cancer". Cancer Genetics and Cytogenetics, 119(2), 139-145.
Özet: The expression frequency of common fragile sites induced by aphidicolin (Apc), bromodeoxyuridine (BrdU), and caffeine was evaluated on prometaphase chromosomes obtained from the peripheral blood lymphocytes of 32 patients with colon cancer, 30 of their clinically healthy family members and 30 age-matched normal controls. The proportion of-damaged cells (P < 0.001), the mean number of chromosomal aberrations and the expression frequencies of fragile sites were significantly higher in the patient and relative groups compared to the control group. Our findings show an increased genetic instability in patients with colon cancer and their first-degree relatives. In addition, common fragile sites can be used as a suitable marker for determining genetic predisposition to cancer.
URI: https://doi.org/10.1016/S0165-4608(99)00228-9
https://www.sciencedirect.com/science/article/pii/S0165460899002289
http://hdl.handle.net/11452/21759
ISSN: 0165-4608
Koleksiyonlarda Görünür:Scopus
Web of Science

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