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Başlık: Glycyl-glutamine inhibits nicotine conditioned place preference and withdrawal
Yazarlar: Levendusky, Mark C.
Hamilton, Jacob R.
Millington, William
Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı.
Göktalay, Gökhan
Çavun, Sinan
AAH-1448-2021
AAC-9702-2019
Anahtar kelimeler: Pharmacology & pharmacy
Conditioned place preference
Pro-opiomelanocortin
Dipeptide
Beta-endorphin
Nicotine
Opioid
Naloxone
Dependence
Receptor
Smoking
Naltrexone
Cyclic dipeptides
Oligopeptide transporter
Cardiorespiratory depression
Beta-endorphin
Naturally-occurring antagonist
Yayın Tarihi: 13-Oca-2006
Yayıncı: Elsevier
Atıf: Göktalay, G. vd. (2006). ''Glycyl-glutamine inhibits nicotine conditioned place preference and withdrawal''. European Journal of Pharmacology, 530(1-2), 95-102.
Özet: Glycyl-glutamine (Gly-Gln) is an inhibitory dipeptide synthesized from beta-endorphin(1-31). Previously, we showed that Gly-Gln inhibits morphine conditioned place preference, tolerance, dependence and withdrawal. In this study, we tested whether Gly-Gln's inhibitory activity extends to other rewarding drugs, specifically nicotine. Rats were conditioned with nicotine (0.6 mg/kg, s.c.) for four days and tested on day five. Glycyl-glutamine (100 nmol i.c.v.) inhibited acquisition and expression of a nicotine place preference significantly. Cyclo(Gly-Gln) (100 nmol i.c.v. or 25 mg/kg i.p.), a cyclic Gly-Gln derivative, blocked expression of nicotine place preference but Gly-D-Gln (100 nmol i.c.v.) was ineffective. To study nicotine withdrawal, rats were treated with nicotine (9 mg/kg/day) for seven days and conditioned place aversion was induced with mecamylamine (1 mg/kg, s.c.). Glycyl-glutamine blocked acquisition of place aversion to mecamylamine but not U50,488, a kappa opioid receptor agonist. Glycyl-glutamine thus inhibits the rewarding effects of nicotine and attenuates withdrawal in nicotine dependent rats.
URI: https://doi.org/10.1016/j.ejphar.2005.11.034
https://www.sciencedirect.com/science/article/pii/S0014299905012203
http://hdl.handle.net/11452/21798
ISSN: 0014-2999
1879-0712
Koleksiyonlarda Görünür:Scopus
Web of Science

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