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Başlık: Hepatocellular carcinoma in children and effect of living-donor liver transplantation on outcome
Yazarlar: Arıkan, Çiğdem
Kılıç, Murat
Nart, Deniz
Özgenç, Funda
Tokat, Yaman
Yağcı, Raşit V.
Aydoğdu, Sema
Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik Gastroenteroloji, Hepatoloji ve Beslenme Anabilim Dalı.
Özkan, Tuğba
7004474005
Anahtar kelimeler: Pediatrics
Transplantation
Survival
Pediatric liver transplantation
Pediatric end-stage liver disease score
Model for end-stage liver disease score for hepatocellular carcinoma
Chronic liver disease
Hepatocellular carcinoma
Tumors
Criteria
Survival
Cirrhosis
Infection
Hepatoblastoma
Childhood
Natural-history
Yayın Tarihi: 2006
Yayıncı: Wiley
Atıf: Arıkan, C. vd. (2006). ''Hepatocellular carcinoma in children and effect of living-donor liver transplantation on outcome''. Pediatric Transplantation, 10(1), 42-47.
Özet: Hepatocellular carcinoma (HCC) is primarily observed in the older children and in most cases it develops in association with liver cirrhosis. Liver transplantation offers a good chance for long-term cure. To evaluate the outcome of children with HCC and the impact of living-donor orthotopic liver transplantation (OLT) on survival a retrospective review of radiographic, laboratory, pathologic, and therapeutic data in 13 children (six female and seven male) with chronic liver disease accompanied with HCC were studied. The patients were divided into two groups according to therapeutic modality: transplanted and non-transplanted patients. Kaplan-Meier survival curves in various therapeutic groups were plotted. The mean age of patients was 6.4 +/- 4.8 yr. Pediatric end-stage liver disease score was adapted to model for end-stage liver disease score for HCC and ranged between 1-44 and 18-44, respectively. The underlying liver diseases were tyrosinemia type 1 (n = 6), chronic hepatitis B infection (n equals;6), glycogen storage disease type 1 (n = 1). Alfa-feto protein levels were elevated in all patients except one. Median number of tumor nodules was three (1-10), median maximal diameter of tumor nodules was 3.4 cm (0.5-8). Eleven patients were eligible for OLT whereas two patients were not eligible. Seven of the 11 patients considered for transplantation underwent living-donor OLT. Remaining four patients died while waiting on cadaveric transplant list. Overall 1 and 4-yr survival rates for all patients were 53.3 and 26.6%, respectively, and were found significantly higher in transplanted children than non-transplanted children (72%, 72% vs. 33% and 16.6%). No patient had tumor recurrence at median of 36-month follow-up after OLT. OLT is a life-saving procedure for children with chronic liver disease accompanying with HCC. Living-donor OLT avoids the risk of tumor progression and transplant ineligibility in these children.
URI: https://doi.org/10.1111/j.1399-3046.2005.00395.x
https://onlinelibrary.wiley.com/doi/10.1111/j.1399-3046.2005.00395.x
http://hdl.handle.net/11452/21855
ISSN: 1397-3142
1399-3046
Koleksiyonlarda Görünür:Scopus
Web of Science

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