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Başlık: Vitamin A deficiency in patients with common variable immunodeficiency
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik İmmünoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya ve Klinik Biyokimya Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.
0000-0001-8571-2581
Kılıç, Sara Şebnem
Kezer, Esra Yapıcı
İlçöl, Yeşim Özarda
Aydın, Sami
Yakut, Tahsin
Ulus, İsmail Hakkı
D-5340-2015
AAL-8873-2021
AAH-1658-2021
34975059200
8579338600
55665181500
6602802424
7005387015
7004271086
Anahtar kelimeler: Vitamin A
Common variable immunodeficiency
Cytokine
Neopterin
Retinol
Serum
Immunology
Yayın Tarihi: May-2005
Yayıncı: Springer/Plenum Publishers
Atıf: Kılıç, S. S. vd. (2005). "Vitamin A deficiency in patients with common variable immunodeficiency". Journal of Clinical Immunology, 25(3), 275-280.
Özet: Vitamin A, a naturally occuring antioxidant micronutrient, has immunomodulating effect in patients with immunodeficiency, including an influence on cytokine production and lymphocyte growth and functions. Vitamin A deficiency is associated with a shift from type 2 cytokines to predominantly type I cytokines. The aims of this study were to determine Vitamin A status in Common variable immunodeficiency (CVID) patients and the relationship between Vitamin A status and cytokines production. Serum Vitamin A, neopterin, TNF-alpha, IL-2, IL-4, and IL-10 levels were determined in 19 CVID patients and 15 healthy children. Effects of 9-cis retinal, Vitamin A derivative, on cytokines (TNF-alpha, IL-2, IL-4 and IL-10) production in lymphocytes were tested in vitro condition using lymphocyte cultures obtained from CVID patients and healthy children. Serum Vitamin A level in CVDI patients was, 21.1 +/- 1.5 mu g/dL, significantly (p < 0.001) lower than the value, 35.7 +/- 1.8 mu g/dL, observed in healthy children. Serum neopterin level in the patients was, 9.8 +/- 2.9 nmol/L, higher (p < 0.05) than the value, 3.9 +/- 0.7 nmol/L, observed in control group. Common variable immunodeficiency patients, serum IL-4 level was significantly (p < 0.05) lower than the value observed for healthy children. Serum TNF-alpha, IL-2 and IL-10 levels were similar in the patients and healthy children. Vitamin A derivative, 9-cis retinal, increased TNF-alpha and IL-4 production in cultured mononuclear cells obtained from control and CVID patients. Vitamin A derivative, also, increased IL-2 and Il-4 production in cultured mononuclear cells obtained from CVID patients. These results show that CVID patients have low serum Vitamin A levels and high serum neopterin levels. A supplementation with Vitamin A may have role in downregulation of inflammatory responses in CVID patients.
URI: https://doi.org/10.1007/s10875-005-4090-6
https://link.springer.com/article/10.1007%2Fs10875-005-4090-6
http://hdl.handle.net/11452/21861
ISSN: 0271-9142
1573-2592
Koleksiyonlarda Görünür:Scopus
Web of Science

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