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Başlık: Intravenous administration of choline or CDP-choline improves platelet count and platelet closure times in endotoxin-treated dogs
Yazarlar: Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı.
0000-0001-9836-0749
Yılmaz, Zeki
İlcol, Yeşim Özarda
Torun, Serhat
Ulus, İsmail Hakkı
D-5340-2015
A-9637-2008
AAL-8873-2021
Anahtar kelimeler: General & internal medicine
Hematology
Surgery
Cardiovascular system & cardiology
CDP-choline
Choline
Dog
Endotoxemia
PFA-100
Platelet
Roles
Augments
Rat
Shocks
Cytidine
Function analyzer
Yayın Tarihi: 2006
Yayıncı: Lippincott Williams
Atıf: Yılmaz, Z. vd. (2006). ''Intravenous administration of choline or CDP-choline improves platelet count and platelet closure times in endotoxin-treated dogs''. Shock, 25(1), 73-79.
Özet: This study was performed to assess the effects of intravenous choline chloride and cytidine-5'-diphosphate choline (CDP-choline) treatments on circulating platelet, white blood cell, and red blood cell counts and platelet functions in response to endotoxin. Saline (0.2 mL/kg), choline chloride (20 mg/kg), or CDP-choline (70 mg/kg) were given intravenously three times at 4-h intervals, and endotoxemia was induced by endotoxin (E. coli 055:B5, 20 mu g/kg) infusion, 5 min after the first treatment. Blood samples were collected before and at multiple time points after the challenge, for a panel of hematologic parameters and platelet closure times measured by PFA-100 (TM). In saline-treated dogs, circulating platelet counts decreased by 85% (P < 0.001) at 0.5 h and remained low by 36%-80% (P < 0.5-0.001) 1-12 h after endotoxin. Circulating WBC counts decreased by 80%-90% (P < 0.001) at 0.5-2 h, and increased (P < 0.001) by 190% 12 h after the endotoxin. In response to endotoxin, RBCs increased by 10%-13% (P < 0.05) at 1-12 h. Endotoxin-induced decline in circulating platelets was attenuated at 0.5 h (P < 0.05--0.01) and reversed at 1-12 h (P < 0.05-0.001) by choline. Platelet closure times were shortened from 81 +/- 10 s and 135 +/- 10 s to 29 +/- 5 s (P < 0.001) and 60 +/- 3 s (P < 0.001) at 0.5 h, and prolonged (P < 0.001) at 1-8 h after endotoxin induction. Endotoxin-induced shortening in platelet closure times was attenuated (P < 0.05) and blocked (P < 0.01) by choline and CDP-choline, respectively. These results showed that choline and CDP-choline treatments improved circulating platelet counts and platelet function during endotoxemia in dogs.
URI: https://doi.org/10.1097/01.shk.0000185796.04589.15
https://journals.lww.com/shockjournal/Fulltext/2006/01000/INTRAVENOUS_ADMINISTRATION_OF_CHOLINE_OR.13.aspx
http://hdl.handle.net/11452/21914
ISSN: 1073-2322
1540-0514
Koleksiyonlarda Görünür:Scopus
Web of Science

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