1. Açık Erişim@BUU
  2. İndeksli Yayınlar
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Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/22214
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dc.date.accessioned2021-10-04T08:40:24Z-
dc.date.available2021-10-04T08:40:24Z-
dc.date.issued1997-
dc.identifier.citationEgeli, U. ve Tunca, B. (1997). "Detection of fragile sites induced by pyrimethamine". Teratogenesis Carcinogenesis and Mutagenesis, 17(2), 59-69.en_US
dc.identifier.issn0270-3211-
dc.identifier.urihttps://doi.org/10.1002/(SICI)1520-6866(1997)17:2<59::AID-TCM2>3.0.CO;2-D-
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/(SICI)1520-6866(1997)17:2%3C59::AID-TCM2%3E3.0.CO;2-D-
dc.identifier.urihttp://hdl.handle.net/11452/22214-
dc.description.abstractIn this study, the effect of pyrimethamine in inducing expression of fragile sites in human peripheral blood lymphocyte cultures is investigated. In vitro lymphocyte cultures of 15 healthy individuals were treated with 0.02 mg/ml of pyrimethamine for 48 and 72 hr. One culture was used as control. The number of cells showing chromosomal aberration increases significantly in the cultures after 48 and 72 hr in comparison to the control group (P < 0.001). Localization of fragile sites was determined by the G-banding method and light microscopy. As a result, five folic acid-sensitive fragile sites (lp32, lq32. 3p14, 6p22, 14q24) were detected.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOncologyen_US
dc.subjectGenetics & heredityen_US
dc.subjectToxicologyen_US
dc.subjectPyrimethamineen_US
dc.subjectFragile siteen_US
dc.subjectLymphocyte cultureen_US
dc.subjectChromosomal aberrationsen_US
dc.subjectG-bandingen_US
dc.subjectHuman-chromosomesen_US
dc.subjectDihydrofolate-reductaseen_US
dc.subjectCanceren_US
dc.subjectMethotrexateen_US
dc.subjectExpressionen_US
dc.subjectRearrangementsen_US
dc.subjectAberrationsen_US
dc.subject.meshAdulten_US
dc.subject.meshAntimalarialsen_US
dc.subject.meshCell culture techniquesen_US
dc.subject.meshChromosome aberrationsen_US
dc.subject.meshChromosome bandingen_US
dc.subject.meshChromosome fragile sitesen_US
dc.subject.meshChromosome fragilityen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshLymphocytesen_US
dc.subject.meshMaleen_US
dc.subject.meshPyrimethamineen_US
dc.titleDetection of fragile sites induced by pyrimethamineen_US
dc.typeArticleen_US
dc.identifier.wosA1997XN84000002tr_TR
dc.identifier.scopus2-s2.0-0030811917tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Fen Edebiyat Fakültesi/Moleküler Biyoloji Bölümü.tr_TR
dc.contributor.orcid0000-0002-1619-6680tr_TR
dc.identifier.startpage59tr_TR
dc.identifier.endpage69tr_TR
dc.identifier.volume17tr_TR
dc.identifier.issue2tr_TR
dc.relation.journalTeratogenesis Carcinogenesis and Mutagenesisen_US
dc.contributor.buuauthorEgeli, Ünal-
dc.contributor.buuauthorTunca, Berrin-
dc.contributor.researcheridABI-6078-2020tr_TR
dc.identifier.pubmed9261920tr_TR
dc.subject.wosOncologyen_US
dc.subject.wosGenetics & heredityen_US
dc.subject.wosToxicologyen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubmeden_US
dc.wos.quartileQ4en_US
dc.contributor.scopusid55665145000tr_TR
dc.contributor.scopusid6602965754tr_TR
dc.subject.scopusHyperpigmentation; Vitamin B 12 Deficiency; Megaloblastic Anemiaen_US
dc.subject.emtreePyrimethamineen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeChromosome aberrationen_US
dc.subject.emtreeChromosome fragile sitetr_TRen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGenotoxicityen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreeLymphocyte cultureen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreePriority journalen_US
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