1. Açık Erişim@BUU
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Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/22214
Title: Detection of fragile sites induced by pyrimethamine
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.
Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Moleküler Biyoloji Bölümü.
0000-0002-1619-6680
Egeli, Ünal
Tunca, Berrin
ABI-6078-2020
55665145000
6602965754
Keywords: Oncology
Genetics & heredity
Toxicology
Pyrimethamine
Fragile site
Lymphocyte culture
Chromosomal aberrations
G-banding
Human-chromosomes
Dihydrofolate-reductase
Cancer
Methotrexate
Expression
Rearrangements
Aberrations
Issue Date: 1997
Publisher: Wiley
Citation: Egeli, U. ve Tunca, B. (1997). "Detection of fragile sites induced by pyrimethamine". Teratogenesis Carcinogenesis and Mutagenesis, 17(2), 59-69.
Abstract: In this study, the effect of pyrimethamine in inducing expression of fragile sites in human peripheral blood lymphocyte cultures is investigated. In vitro lymphocyte cultures of 15 healthy individuals were treated with 0.02 mg/ml of pyrimethamine for 48 and 72 hr. One culture was used as control. The number of cells showing chromosomal aberration increases significantly in the cultures after 48 and 72 hr in comparison to the control group (P < 0.001). Localization of fragile sites was determined by the G-banding method and light microscopy. As a result, five folic acid-sensitive fragile sites (lp32, lq32. 3p14, 6p22, 14q24) were detected.
URI: https://doi.org/10.1002/(SICI)1520-6866(1997)17:2<59::AID-TCM2>3.0.CO;2-D
https://onlinelibrary.wiley.com/doi/10.1002/(SICI)1520-6866(1997)17:2%3C59::AID-TCM2%3E3.0.CO;2-D
http://hdl.handle.net/11452/22214
ISSN: 0270-3211
Appears in Collections:Scopus
Web of Science

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