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Başlık: The effect of vitamin A on CCl4-induced hepatic injuries in rats: a histochemical, immunohistochemical and ultrastructural study
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.
0000-0001-5757-8450
Noyan, Semiha
Çavuşoğlu, İlkin
Minbay, F. Zehra
ABC-1475-2020
56636269700
56009155800
12040872100
Anahtar kelimeler: Cell biology
Ito cells
Vitamin A
Desmin
Alpha-smooth muscle actin
Alpha-SMA
Fibrosis
Collagen types
Transitional cell
Extracellular-matrix
Perisinusoidal cells
Carbon-tetrachloride
Smooth-muscle-actin
Alcoholic liver-injury
Fat-storing cells
Animalia
Living systems studies
Impregnation
Gold
Diseases
Carbon inorganic compounds
Cell culture
a-SMA
a-smooth muscle actin
Vitamins
Yayın Tarihi: 2006
Yayıncı: Elsevier
Atıf: Noyan, S. vd. (2006). ''The effect of vitamin A on CCl4-induced hepatic injuries in rats: a histochemical, immunohistochemical and ultrastructural study''. Acta Histochemica, 107(6), 421-434.
Özet: In this study, we aimed to investigate the effect of vitamin A on the transformation of the Ito cells to fibrogenic form and suppression of the development of fibrosis. Carbon tetrachloride intoxication was performed on rats for 2, 8, 12 or 20 weeks and 5 x 10(4) IU vitamin A (as retinol palmitate) was injected subcutaneously once every 4 weeks. Ito cells were detected by gold chloride impregnation, as well as desmin and alpha-smooth muscle actin (alpha-SMA) immunohistochemistry. Additionally, all groups were examined ultrastructurally. The number of Ito cells that were labelled positively with gold impregnation decreased in the fibrotic groups; however, alpha-SMA and desmin immunopositive Ito cells increased. The samples from animals that were treated with vitamin A showed an increase in labelling with gold impregnation but a decrease in alpha-SMA immunopositivity. The data showed that vitamin A can prevent hepatic injury, by suppressing the transformation of Ito cells to fibrogenic form. We conclude that vitamin A has potential for the treatment of hepatic fibrotic diseases. alpha-SMA immunohistochemistry was found to be more informative than desmin immunohistochemistry for monitoring Liver fibrosis.
URI: https://doi.org/10.1016/j.acthis.2005.09.001
https://www.sciencedirect.com/science/article/pii/S0065128105000838
http://hdl.handle.net/11452/22258
ISSN: 0065-1281
Koleksiyonlarda Görünür:Scopus
Web of Science

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