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Başlık: Oxidizability of apolipoprotein B-containing lipoproteins and serum paraoxonase/arylesterase activities in preeclampsia
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.
0000-0002-2593-7196
Sarandöl, Emre
Şafak, Özlem
Melahat, Dirican
Uncu, Gürkan
ABE-1716-2020
AAG-6985-2021
55943324800
6508363078
6601919847
6603716169
Anahtar kelimeler: Arylesterase
Lipoprotein oxidation
Malondialdehyde
Paraoxonase
Preeclampsia
Low-density-lipoprotein
Pregnancy-induced hypertension
Endothelial dysfunction
Oxidative modification
Paraoxonase arylesterase
Lipid-peroxidation
HDL-cholesterol
Vitamin-E
Plasma
Women
Medical laboratory technology
Yayın Tarihi: Kas-2004
Yayıncı: Pergamon-Elsevier Science
Atıf: Sarandöl, E. vd. (2004). “Oxidizability of apolipoprotein B-containing lipoproteins and serum paraoxonase/arylesterase activities in preeclampsia”. Clinical Biochemistry, 37(11), 990-996.
Özet: Lipoprotein oxidation has been implicated in the pathogenesis of preeclampsia and paraoxonase, an antioxidant enzyme shown to protect lipoproteins from being oxidized. The aim of the present study was to evaluate oxidizability of apolipoprotein B-containing lipoproteins and serum paraoxonase/arylesterase activities in preeclampsia. Twenty-one women with mild preeclampsia, 21 women with severe preeclampsia, and 20 women with normal uncomplicated pregnancy were included in this study. Serum malondialdehyde (MDA) level, an indicator of lipid peroxidation, was measured by high-performance liquid chromatography (HPLC). The oxidizability of apolipoprotein B-containing lipoproteins was evaluated by copper-induced in vitro peroxidation of the isolated fraction of apolipoprotein B-containing lipoproteins coupled with the thiobarbituric acid-reactive substances assay and expressed as the difference between copper-treated MDA and basal MDA (ΔMDA). The serum paraoxonase and arylesterase activities were determined spectrophotometrically. Serum MDA and ΔMDA levels of apolipoprotein B-containing lipoproteins were significantly higher in both mild and severe preeclampsia groups than in the normal pregnant group. Serum paraoxonase and arylesterase activities were not significantly different among the study groups. Enhancement in oxidizability of apolipoprotein B-containing lipoproteins accompanying with dyslipidemia and increased serum MDA levels suggests that those lipoproteins play a role in the pathogenesis of preeclampsia. Further studies are needed to investigate serum paraoxonase activity in women with normal pregnancies and preeclampsia.
URI: https://doi.org/10.1016/j.clinbiochem.2004.06.013
https://www.sciencedirect.com/science/article/pii/S0009912004001791
http://hdl.handle.net/11452/22286
ISSN: 0009-9120
Koleksiyonlarda Görünür:Scopus
Web of Science

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