The in vivo and in vitro comparative nephrotoxicity of cefazolin and gentamicin

Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/22636

Title:	The in vivo and in vitro comparative nephrotoxicity of cefazolin and gentamicin
Authors:	Yılmaz, Orhan Çabalar, Mehmet Uludağ Üniversitesi/Veterinerlik Fakültesi/Patoloji Anabilim Dalı. Özbilgin, Selda 57225240619
Keywords:	Toxicology Veterinary sciences Gamma-glutamyl-transferase Cephalosporin Dogs Rats Animalia Oryctolagus cuniculus
Issue Date:	1999
Publisher:	Comparative Toxicology Lab
Citation:	Yılmaz, O. vd. (1999). "The in vivo and in vitro comparative nephrotoxicity of cefazolin and gentamicin". Veterinary and Human Toxicology, 41(4), 222-225.
Abstract:	Biochemical, histopathological and cell culture evaluations compared the nephrotoxicity of cefazolin with that of gentamicin. New Zealand rabbits were dosed with 250 mg cefazolin/animal im twice daily, 3 mg gentamicin/kg im twice daily, or 0.9% NaCl solution for 10 d. The rabbits in drug-treated groups had necrosis of proximal kidney tubules and elevated urinary-gamma glutamyl transferase (uGGT) levels. The results of the histopathological examinations, uGGT analyses and effects in cell culture indicated the nephrotoxicities of both antibiotics were similar.
URI:	http://hdl.handle.net/11452/22636
ISSN:	0145-6296
Appears in Collections:	Scopus Web of Science

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