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http://hdl.handle.net/11452/22650| Title: | Decreased plasma levels of soluble receptor for advanced glycation endproducts (sRAGE) in patients with nonalcoholic fatty liver disease |
| Authors: | Atuğ, Özlen Yılmaz, Yusuf Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı. Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji Anabilim Dalı. Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı. 0000-0003-2467-9356 0000-0003-0463-6818 0000-0003-4518-5283 Ulukaya, Engin Gül, Özen Öz Arabul, Mahmut Gül, Cuma Bülent Oral, Arzu Yılmaztepe Aker, Sibel Dolar, Mahmut Enver A-7063-2018 AAI-1005-2021 AAG-9177-2021 A-5841-2017 K-5792-2018 22936014300 6602927353 26040787100 15925230900 23988796000 23091316500 12795285000 6602075084 |
| Keywords: | Fatty liver Biological markers Receptor for advanced glycation endproducts (RAGE) Enzyme-linked immunosorbent assay End-products ages Insulin-resistance Serum-levels Rage Form Pathogenesis Galectin-3 Protein Medical laboratory technology |
| Issue Date: | Jun-2009 |
| Publisher: | Pergamon-Elsevier Science |
| Citation: | Yılmaz, Y. vd. (2009). "Decreased plasma levels of soluble receptor for advanced glycation endproducts (sRAGE) in patients with nonalcoholic fatty liver disease". Clinical Biochemistry, 42(9), 802-807. |
| Abstract: | Objectives: Levels of soluble receptor for advanced glycation endproducts (sRAGE) have been linked to several components of the metabolic syndrome. We tested the hypothesis that plasma levels of sRAGE may be associated with non-alcoholic fatty liver disease. Design and methods: We enrolled subjects with definite nonalcoholic steatohepatitis (NASH, n=40), borderline NASH (n=8), simple fatty liver (n=9) and healthy controls (n=14). Plasma levels of sRAGE were measured by ELISA. Results: Concentrations of sRAGE were significantly lower in patients with definite NASH (1080 +/- 392 pg/mL, P<0.01) and borderline NASH (1050 +/- 278 pg/mL, P<0.05) compared to controls (1480 +/- 387 pg/mL). Levels of sRAGE were significantly and inversely correlated with ALT (r=-0.30, P<0.05) and AST (r=-0.23, P<0.05). Conclusion: Plasma levels of sRAGE are significantly reduced in definite and borderline NASH. |
| URI: | https://doi.org/10.1016/j.clinbiochem.2009.02.003 https://www.sciencedirect.com/science/article/pii/S0009912009000848 http://hdl.handle.net/11452/22650 |
| ISSN: | 0009-9120 |
| Appears in Collections: | Scopus Web of Science |
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