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Başlık: Cell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small cell lung cancer cells in vitro
Yazarlar: Dimas, Konstantinos
Sakellaridis, Nikos
Uludağ Üniversitesi/Tıp Fakültesi/Klinik Biyokimya Anabilim Dalı.
Uludağ Üniversitesi/Fen-Edebiyat/Kimya Anabilim Dalı.
Uludağ Üniversitesi/Fen-Edebiyat/Biyoloji Anabilim Dalı.
0000-0002-6729-7908
0000-0003-2647-5875
Ulukaya, Engin
Arı, Ferda
Sarımahmut, Mehmet
Güney, Emel
Yılmaz, Veysel T.
AAG-7012-2021
K-5792-2018
AAG-8288-2021
6602927353
24376085300
44661687400
25027291500
7006269202
Anahtar kelimeler: Oncology
Lung cancer treatment
Palladium(II) and platinum(II) complexes
Necrosis
Cytotoxic activity
Crystal-structure
Antitumor agents
Cisplatin
Pd(II)
Dna
Apoptosis
Pt(II)
Assay
Hepatotoxicity
Yayın Tarihi: Eki-2011
Yayıncı: Springer
Atıf: Ulukaya, E. vd. (2011). " Cell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small cell lung cancer cells in vitro ". Journal of Cancer Research and Clinical Oncology, 137(10),1425-1434.
Özet: Purpose Treatment for lung cancer is still far from satisfying rates. Therefore, there is a need for novel anticancer agents. For this purpose, novel platinum and palladium complexes {[Pd(sac)(terpy)](sac).4H(2)O (Complex 1), [Pt(sac)(terpy)] (sac).5H(2)O (Complex 2), [PdCl(terpy)](sac).2H(2)O (Complex 3), [PtCl(terpy)](sac).2H(2)O (Complex 4)} have been tested against three different non-small cell lung cancer cell lines (A549, H1299, PC-3). Methods Growth-inhibiting effcts have been tested by the MTT and ATP viability assays. Apoptosis has been detected by the caspase-cleaved cytokeratin 18 (M30-antigen) assay. Necrosis has been detected by staining the cells with fluorescent dyes. Mitotic index has been calculated by counting the mitotic figures after staining with hematoxylin. Results The complex 3 exhibited significant anti-growth effects, and its anti-growth effect was more powerful than that of cisplatin that is a standard chemotherapeutic agent for this type of cancer. The complexes did not induce apoptosis, while necrosis clearly took place. Conclusions Novel Pd(II) complex ([PdCl(terpy)] (sac).2H(2)O) seems to represent a potentially active drug against non-small cell lung cancer cell lines, and further studies in vivo are warranted.
URI: https://doi.org/10.1007/s00432-011-1021-1
https://link.springer.com/article/10.1007/s00432-011-1021-1
http://hdl.handle.net/11452/22667
ISSN: 0171-5216
Koleksiyonlarda Görünür:Scopus
Web of Science

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