Bu öğeden alıntı yapmak, öğeye bağlanmak için bu tanımlayıcıyı kullanınız: http://hdl.handle.net/11452/22682
Başlık: Relation between lipoprotein (a) and in vitro oxidation of apolipoprotein B-containing lipoproteins
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.
0000-0002-2593-7196
Serdar, Zehra
Sarandöl, Emre
Dirican, Melahat
Yeşilbursa, Dilek
Serdar, Akın
Tokullugil, Asuman
ABE-1716-2020
AAG-6985-2021
57222002284
55943324800
6601919847
36658194500
6603403111
6507662010
Anahtar kelimeler: Medical laboratory technology
Lipoprotein (a)
Lipoprotein oxidation
Antioxidants
Coronary artery disease
Low-density-lipoprotein
Middle-aged men
Vitamin-e consumption
Heart-disease
Myocardial-infarction
Risk-factors
Elevated lipoprotein(a)
Antioxidant vitamins
Predictive value
Yayın Tarihi: 2000
Yayıncı: Pergamon-Elsevier Science
Atıf: Serdar, Z. vd. (2000). "Relation between lipoprotein (a) and in vitro oxidation of apolipoprotein B-containing lipoproteins". Clinical Biochemistry, 33(4), 303-309.
Özet: Objectives: To assess the relationship between lipoprotein (a) [Lp (a)] and lipoprotein oxidation in patients with coronary artery disease (CAD). Design and methods: Oxidation of apolipoprotein (apo)B-containing lipoproteins, vitamin E, carotenoids, lipid-lipoprotein levels were determined in 171 CAD and 70 non-CAD subjects. Results: In CAD patients with Lp (a) concentrations greater than or equal to 30 mg/dL; total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), malondialdehyde (MDA), and apo B levels were significantly higher and lag-time and age were significantly lower than those of CAD patients with Lp (a) concentrations < 30 mg/dL. In non-CAD subjects with Lp (a) concentrations a 30 mg/dL; TC, LDL-C, and vitamin E levels were significantly higher and lag-time was significantly lower than those of non-CAD subjects with Lp (a) concentrations < 30 mg/dL. In CAD patients, Lp (a) correlated negatively with lag-time and positively with MDA levels. Lp (a) correlated negatively with lag-time and vitamin E levels in non-CAD subjects. Conclusions: We have shown that plasma apo B-containing lipoproteins of both CAD and non-CAD subjects with Lp (a) levels 30 mg/dL are more susceptible to in vitro oxidative modification than those of subjects with Lp (a) levels < 30 mg/dL. The relationship between Lp (a) and enhanced susceptibility of apo B-containing lipoproteins to oxidation, appears to support routine investigation of Lp (a).
URI: https://doi.org/10.1016/S0009-9120(00)00079-5
https://www.sciencedirect.com/science/article/pii/S0009912000000795
http://hdl.handle.net/11452/22682
ISSN: 0009-9120
Koleksiyonlarda Görünür:Scopus
Web of Science

Bu öğenin dosyaları:
Bu öğeyle ilişkili dosya bulunmamaktadır.


DSpace'deki bütün öğeler, aksi belirtilmedikçe, tüm hakları saklı tutulmak şartıyla telif hakkı ile korunmaktadır.