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Başlık: Chromosomal fragile sites and relationship between genetic predisposition to small cell lung cancer
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Moleküler Biyoloji ve Genetik Anabilim Dalı.
0000-0002-1619-6680
0000-0002-3820-424X
Tuncay, Berrin
Cecener, Gülşah
Engeli, U.
Gözü, Oktay
Karadağ, M.
Özyardımcı, N.
Edward, Ege
ABI-6078-2020
AAP-9988-2020
23103142200
6602965754
6508156530
6701760348
6505942273
6701341320
8833423400
Anahtar kelimeler: Nonrandom distribution
Small cell lung cancer
Chromosome aberration
Chromosome aberration
Common fragile sites
Genetic pre-disposition
Peripheric blood lymphocyte cultures
Breast-cancershort arm
Expression frequency
Renal-cell
Fhit gene
Heterozygosity
Aphidicolin
Lymphocytes
Susceptibility
Oncology
Genetics & heredity
Toxicology
Mammalia
Yayın Tarihi: 2002
Yayıncı: Wiley
Atıf: Karadağ, M. vd. (2002)."Chromosomal fragile sites and relationship between genetic predisposition to small cell lung cancer". Teratogenesis Carcinogenesis and Mutagenesis, 22(1), 31-40.
Özet: Fragile sites are non-staining gaps and breaks on mammalian chromosomes. Several investigators have pointed out that these sites may act as factors that predispose to specific chromosomal rearrangements that are present in some cancer cases. The expression of common fragile sites induced by aphidicolin (Ape) was evaluated on prometaphase chromosomes obtained from the peripheral blood lymphocytes of 15 patients with lung cancer, 20 of their clinically healthy family members, and 20 age-matched normal controls. As a result of cytogenetic evaluation carried out by the High Resolution Banding (HRB) technique, 1q21, 2q33, 3p14, 7q32, 13q13, 16q23, 17q21, and 22q12 are defined as fragile sites in patients and relatives. The rate of total fragile sites and 2q33, 3p14, and 16q23 are statistically significant in both patients and relatives when compared with the control group. Therefore, our results showed that common fragile sites might be unstable factors in the human genome and they can be used as suitable markers for genetic predisposition to lung cancer.
URI: https://doi.org/10.1002/tcm.1036
https://onlinelibrary.wiley.com/doi/10.1002/tcm.1036
http://hdl.handle.net/11452/22722
ISSN: 0270-3211
Koleksiyonlarda Görünür:Scopus
Web of Science

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