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Başlık: Disturbed dental development of permanent teeth in children with solid tumors and lymphomas
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Diş Bakım Ünitesi.
Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik Onkoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
0000-0002-1480-2907
0000-0002-2382-290X
Çubukçu, Çiğdem Elbek
Sevinir, Betül
Ercan, İlker
AAH-2726-2021
AAH-1570-2021
15062319400
6603199915
6603789069
Anahtar kelimeler: Oncology
Hematology
Pediatrics
Adverse effects
Anticancer treatment
Child
Permanent dentition
Childhood-cancer survivors
Stem-cell transplantation
Long-term survivors
Chemotherapy
Leukemia
Yayın Tarihi: Oca-2012
Yayıncı: Wiley
Atıf: Çubukçu, Ç. E. vd. (2012). "Disturbed dental development of permanent teeth in children with solid tumors and lymphomas". Pediatric Blood and Cancer, 58(1), 80-84.
Özet: Background. Deficient dental root development has been reported after conventional pediatric anticancer therapy but less information is available on children with solid tumors and lymphomas. Procedure. We examined dental development from panoramic radiographs (PRGs) of 37 childhood cancer survivors (CCS) treated under the age of 10 years with multimodal chemotherapy (CT) and/or head and neck radiotherapy (RT). A novel defect index (DeI) was used to describe the total damage to permanent dentition. The DeI was also tested in matched controls. Results. All CCS had dental disturbances including abnormal root development (86.4%), microdontia (13.5%) and tooth agenesis (16.2%). Testing the controls gave the mean DeI value 1.9 +/- 2.7(range, 0-12), while the index scores in the study group varied from 0 to 49 (mean 10.8 +/- 11.2) (P < 0.01). The statistical differences in the mean DeI values were insignificant between CT and CT and RT groups (P > 0.05). Conclusions. Children treated for solid tumors and lymphomas are at considerable risk of some disturbances in developing dental structures. RT increased the severity of disturbances induced by CT. Studies should further elucidate dose-, age and time-related effects of anticancer treatment on dental development.
URI: https://doi.org/10.1002/pbc.22902
https://onlinelibrary.wiley.com/doi/10.1002/pbc.22902
http://hdl.handle.net/11452/22777
ISSN: 1545-5009
1545-5017
Koleksiyonlarda Görünür:Scopus
Web of Science

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