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Başlık: Higher serum nitrate levels are associated with poor survival in lung cancer patients
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları ve Tüberküloz Anabilim Dalı.
0000-0003-0463-6818
0000-0002-9027-1132
Çolakoğulları, Mukaddes
Ulukaya, Engin
Yılmaztepe, Arzu
Ocakoğlu, Gökhan
Yılmaz, Meryem
Karadağ, Mehmet
Tokullugil, Asuman
A-5841-2017
AAG-8744-2021
K-5792-2018
AAH-5180-2021
14423975800
6602927353
8606136100
15832295800
57197051873
6601970351
6507662010
Anahtar kelimeler: Medical laboratory technology
Vascular endothelial growth factor-A (VEGF-A)
Survival
Serum nitrite/nitrate
Nitric oxide (NO)
Lung cancer
Activation
Roles
Cisplatin
Metastasis
Expression
Angiogenesis
Small-cell
P53 gene mutation
Nitric-oxide synthase
Endothelial growth-factor
Yayın Tarihi: 2006
Yayıncı: Pergamon-Elsevier Science
Atıf: Çolakoğulları, M. vd. (2006). ''Higher serum nitrate levels are associated with poor survival in lung cancer patients''. Clinical Biochemistry, 39(9), 898-903.
Özet: Objectives: Angiogenic factors induce tumour growth and angiogenesis which leads to tumour metastasis and a poor survival rate. This study aimed to assess the possible roles of nitric oxide (NO) and vascular endothelial growth factor-A (VEGF-A) in the overall survival of patients with late stage lung cancer. Design and methods: The study was carried out with primary lung carcinoma patients (n = 31) and healthy controls (n = 15). Pre- and post-cisplatin-based chemotherapy serum nitrite/nitrate levels were measured as nitrite after enzymatic conversion followed by Griess reaction and serum VEGF-A analysis was performed using ELISA. After patient follow-up, survival rates were calculated by using the Kaplan-Meier method [Dudek et al. Cancer Invest 2005; 23(3):193-200]. Results: The serum nitrite/nitrate and VEGF-A levels of lung cancer patients and the control group were 93.7 +/- 48.9 and 63.7 +/- 32.2 PM (p=0.018), and 620 +/- 491 and 255 +/- 157 pg/mL (p = 0.001), respectively, High nitrite/nitrate (> 67.2 mu M) concentration had statistically significant effects on overall survival (Cox analysis, p = 0.026). The overall survival of the lung cancer patients with higher serum nitrate concentrations was significantly less than the ones with lower serum nitrite/nitrate (Kaplan-Meier survival functions test, log rank significance = 0.0007). Conclusion: Our results suggest that having a high serum nitrite/nitrate concentration is a strong indicator of poor survival for late stage lung cancer patients. However, this conclusion deserves to be elucidated further by using a larger sample size.
URI: https://doi.org/10.1016/j.clinbiochem.2006.06.008
https://www.sciencedirect.com/science/article/pii/S0009912006002153
http://hdl.handle.net/11452/22805
ISSN: 0009-9120
1873-2933
Koleksiyonlarda Görünür:Scopus
Web of Science

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