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Başlık: Possible neuroprotective effects of magnesium sulfate and melatonin as both pre- and post-treatment in a neonatal hypoxic-ischemic rat model
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Saǧlıǧı ve Hastalıkları Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Psikoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı.
0000-0002-4606-6596
0000-0003-3368-8123
Çetinkaya, Merih
Alkan, Tülin
Özyener, Fadil
Kafa, İlker Mustafa
Kurt, Mustafa Ayberk
Köksal, Nilgün
AAH-1792-2021
AAG-7125-2021
AAH-1641-2021
AAG-8393-2021
AAR-4341-2020
23994946300
6601953747
6506242143
8450193200
35603735000
7003323615
Anahtar kelimeler: Pediatrics
Apoptosis
Hypoxia-ischemia
Magnesium sulfate
Melatonin
Neuroprotection
Brain-injury
Birth asphyxia
Newborn rats
Cell-death
Damage
Consequences
Pretreatment
Infusion
Protects
Infants
Rattus
Yayın Tarihi: 2011
Yayıncı: Karger
Atıf: Çetinkaya, M. vd. (2011). ''Possible neuroprotective effects of magnesium sulfate and melatonin as both pre- and post-treatment in a neonatal hypoxic-ischemic rat model''.Neonatology, 99(4), 302-310.
Özet: Background: Perinatal hypoxia-ischemia is a major cause of mortality and long-term neurological deficits. Objectives: The objective of this study was to compare the effects of two neuroprotective agents; magnesium sulfate and melatonin, administered alone or in combination, on brain infarct volume and TUNEL positivity in a neonatal hypoxic-ischemic (HI) rat model. Methods: After being anesthetized, 7-day-old pups (n = 80) underwent ischemia followed by exposure to hypoxia for 2 h. The pups were then divided equally and randomly into 4 groups in order to receive the vehicle (saline, control group), magnesium sulfate, melatonin or a combination of magnesium sulfate and melatonin. Treatments were administered intraperitoneally three times; the first being just before ischemia, the second after hypoxia and the third 24 h after the second dose. The pups were sacrificed on postnatal day 10, their brains harvested and evaluated for infarct volume and neuronal apoptosis. Results: Percent infarcted brain volume was significantly reduced in pups receiving the drugs (either magnesium sulfate, melatonin or their combination) compared with those receiving the vehicle. In addition, TUNEL staining showed markedly reduced numbers of TUNEL-positive cells per unit area in the CA1, CA3 and dentate gyrus regions of the hippocampus and in the cortex. However, no statistically significant differences were found regarding percent infarcted brain volume and number of TUNEL-positive cells among the drug-treated groups. Conclusions: Magnesium sulfate and melatonin, two agents acting at different stages of HI brain damage, administered either alone or in combination, significantly reduced the percent infarcted brain volume and TUNEL positivity, suggesting that these agents may confer a possible benefit in the treatment of infants with HI encephalopathy.
URI: https://doi.org/10.1159/000320643
https://www.karger.com/article/Abstract/320643
http://hdl.handle.net/11452/22872
ISSN: 1661-7800
1661-7819
Koleksiyonlarda Görünür:Web of Science

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